A gene encoding a homologue of dolichol phosphate-β-D-mannose synthase is required for infection of Streptomyces coelicolor A3(2) by phage φC31
A gene encoding a homologue of dolichol phosphate-β-D-mannose synthase is required for infection of Streptomyces coelicolor A3(2) by phage φC31
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DOI：
10.1128/jb.184.21.6081-6083.2002
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发表时间：
2002-11-01
影响因子：
3.2
通讯作者：
Smith, MCM
中科院分区：
文献类型：
--
作者：
Cowlishaw, DA;Smith, MCM
我们之前已经证明，天蓝色链霉菌的 phiC31 感染需要编码真核多甘醇-磷酸-D-甘露糖同源物（蛋白质 O-D-甘露糖基转移酶）的基因。在这里，我们证明编码多甘醇-磷酸-甘露糖合酶同源物的基因对于噬菌体敏感性也是必需的。这些数据证实了天蓝色链球菌 phiC31 噬菌体受体中糖基化的作用。
We have shown previously that a gene encoding a homologue to the eukaryotic dolichol-phosphate-D-mannose, protein O-D-mannosyltransferase, was required for phiC31 infection of Streptomyces coelicolor. Here we show that a gene encoding the homologue to dolichol-phosphate-mannose synthase is also essential for phage sensitivity. These data confirm the role of glycosylation in the phage receptor for phiC31 in S. coelicolor.