Dietary intake of calcium in relation to mortality from cardiovascular disease - The JACC study
Dietary intake of calcium in relation to mortality from cardiovascular disease - The JACC study
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DOI：
10.1161/01.str.0000195155.21143.38
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发表时间：
2006-01-01
期刊：
影响因子：
8.3
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
--
作者：
Umesawa, M;Iso, H;Tamakoshi, A
背景和目的：在日本平均钙摄入量低的人群中，没有前瞻性研究检查钙摄入量与心血管疾病风险之间的关系。方法：1988年至1990年间，110 792名年龄在40至79岁之间、无中风、冠心病或癌症史的日本受试者（46 465名男性和64 327名女性）完成了一份生活方式问卷，包括食物摄入频率，该问卷由日本合作队列（JACC）研究赞助，用于评估癌症风险。到1999年底，经过515029人年的随访，566人死于中风（101人蛛网膜下腔出血，140人肺内出血，273人缺血性中风），234人死于冠心病。结果：总钙摄入量与卒中死亡率呈负相关，但与冠心病或心血管疾病死亡率无关。无论是出血性中风还是缺血性中风，钙摄入量与乳制品的负相关都很明显。乳制品钙摄入量最高五分位数与最低五分位数男性的多因素相对危险度，总卒中为0.53 (95% CI, 0.34 - 0.81)，出血性卒中为0.46(0.23 - 0.91)，缺血性卒中为0.53 (0.29 - 0.99)；女性相应的相对危险度分别为0.57（0.38 ~ 0.86）、0.51（0.28 ~ 0.94）和0.50（0.27 ~ 0.95）。结论：日本男性和女性从乳制品中摄取钙与中风死亡率降低有关。
Background and Purpose - No prospective studies have examined the association between calcium intake and the risk of cardiovascular disease in Japanese populations with a low mean calcium intake.Methods - Between 1988 and 1990, 110 792 Japanese subjects ( 46 465 men and 64 327 women) 40 to 79 years of age without a history of stroke, coronary heart disease, or cancer, completed a lifestyle questionnaire including food intake frequency under the Japan Collaborative Cohort (JACC) Study for Evaluation of Cancer Risk Sponsored by Monbusho. By the end of 1999, after 515 029 person years of follow-up, 566 deaths from stroke ( 101 subarachnoid hemorrhages, 140 intraparenchymal hemorrhages, and 273 ischemic strokes) and 234 deaths from coronary heart disease had been documented.Results - The intake of total calcium tended to be inversely associated with mortality from total stroke but not from coronary heart disease or total cardiovascular disease for men and women. The inverse association with dairy calcium intake was apparent for total stroke, both hemorrhagic and ischemic. The multivariate relative risk for men with highest versus lowest quintiles of dairy calcium intake was 0.53 (95% CI, 0.34 to 0.81) for total stroke, 0.46 (0.23 to 0.91) for hemorrhagic stroke, and 0.53 (0.29 to 0.99) for ischemic stroke; corresponding relative risks for women were 0.57 (0.38 to 0.86), 0.51 (0.28 to 0.94), and 0.50 (0.27 to 0.95).Conclusions - Dietary calcium intake from dairy products was associated with reduced mortality from stroke for Japanese men and women.