Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin
Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin
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DOI：
10.1128/aem.42.1.61-62.1981
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发表时间：
1981-07
影响因子：
4.4
通讯作者：
N. Kyriakidis;E. S. Waight;J. Day;P. Mantle
中科院分区：
文献类型：
--
作者：
N. Kyriakidis;E. S. Waight;J. Day;P. Mantle
从壳青霉中分离出两种新的吲哚代谢产物，并通过高效液相色谱法与其他青霉烯真菌毒素分离。Penitrem D是脱氧-penitrem A。Penitrem E是脱氯-penitrem A，在小鼠中显示出震颤性，尽管它的活性只有penitrem A的三分之一。罗克福汀也首次被证明是皮壳青霉的重要代谢产物。
Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important metabolic product of P. crustosum.