Epidemiological and Virological Characteristics of Influenza in the Western Pacific Region of the World Health Organization, 2006-2010
Epidemiological and Virological Characteristics of Influenza in the Western Pacific Region of the World Health Organization, 2006-2010
复制标题
DOI：
10.1371/journal.pone.0037568
复制
发表时间：
2012-05-29
期刊：
影响因子：
3.7
通讯作者：
Zhang, Wenqing
中科院分区：
文献类型：
--
作者：
Barr, Ian;Hurt, Aeron;Zhang, Wenqing
背景：流感每年引起季节性流行和周期性流行。已经建立了监测流感病毒演变和影响的全球系统，但对监测结果的区域分析有限。本研究描述了2006-2010年世界卫生组织西太平洋区域流感的流行病学和病毒学特征。方法/主要发现：流感样疾病（ILI）和流感病毒数据来自设有国家流感中心的14个国家。数据直接从各国和全球流感监测和应对系统的网络工具fluet获得。五年来，国家流感监测和参与全球系统的情况有所增加。流感病例报告的高峰似乎与流感阳性标本的比例一致。在温带国家，如北半球的蒙古、日本和大韩民国，以及南半球的澳大利亚、新西兰、斐济和新喀里多尼亚（法国），清楚地观察到了流感病毒感染活动的时间格局和流感阳性标本的比例。从2006年到2009年第一季度，中国出现了两次年度活动高峰。热带国家的时间模式不太明显，那里全年都有流感活动。2006年至2009年期间报告的病毒中，甲型流感病毒占大多数，但2010年发现的甲型流感病毒和乙型流感病毒的比例相等。结论/意义：尽管监测方法和强度存在差异，但发现了ILI和流感病毒传播模式的共性。流感流行模式表明，流感流行可能取决于多种因素，包括季节性和人口流动。东南亚国家的优势菌株后来在其他国家被发现。因此，关于流感的及时报告和区域信息共享可作为早期预警，并可帮助各国预测与即将到来的毒株相关的潜在严重程度和负担。
Background: Influenza causes yearly seasonal epidemics and periodic pandemics. Global systems have been established to monitor the evolution and impact of influenza viruses, yet regional analysis of surveillance findings has been limited. This study describes epidemiological and virological characteristics of influenza during 2006-2010 in the World Health Organization's Western Pacific Region.Methodology/Principal Findings: Influenza-like illness (ILI) and influenza virus data were obtained from the 14 countries with National Influenza Centres. Data were obtained directly from countries and from FluNet, the web-based tool of the Global Influenza Surveillance and Response System. National influenza surveillance and participation in the global system increased over the five years. Peaks in ILI reporting appeared to be coincident with the proportion of influenza positive specimens. Temporal patterns of ILI activity and the proportion of influenza positive specimens were clearly observed in temperate countries: Mongolia, Japan and the Republic of Korea in the northern hemisphere, and Australia, New Zealand, Fiji and New Caledonia (France) in the southern hemisphere. Two annual peaks in activity were observed in China from 2006 through the first quarter of 2009. A temporal pattern was less evident in tropical countries, where influenza activity was observed year-round. Influenza A viruses accounted for the majority of viruses reported between 2006 and 2009, but an equal proportion of influenza A and influenza B viruses was detected in 2010.Conclusions/Significance: Despite differences in surveillance methods and intensity, commonalities in ILI and influenza virus circulation patterns were identified. Patterns suggest that influenza circulation may be dependent on a multitude of factors including seasonality and population movement. Dominant strains in Southeast Asian countries were later detected in other countries. Thus, timely reporting and regional sharing of information about influenza may serve as an early warning, and may assist countries to anticipate the potential severity and burden associated with incoming strains.