Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era
Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era
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现代梅毒血清学检测中经典生物学假阳性反应的特征
DOI：
10.1016/j.intimp.2014.03.011
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发表时间：
2014-06-01
影响因子：
5.6
通讯作者：
Yang, Tian-Ci
中科院分区：
文献类型：
--
作者：
Liu, Fan;Liu, Li-Li;Yang, Tian-Ci
为了表征现代CBFP反应，我们分析了2008年5月至2013年2月在厦门大学医学院附属中山医院获得的63，765份血液样本的平行快速血浆反应素（RPR）和梅毒螺旋体颗粒凝集（TPPA）试验结果。在63，765份检测的血液样本中，206份（0.32%）有CBFP反应。在多变量分析中，CBFP反应的可能性增加与女性受试者、≥ 2.80岁受试者和16 - 35岁受试者相关（P <0.05）。在206例受试者中，CBFP反应与17种疾病相关，包括60种疾病。据我们所知，这些疾病中有许多以前没有报道与RPR试验中的CBFP相关，包括假分娩、巨幼细胞性贫血、再生障碍性贫血、包皮过长、先天性心脏畸形和输卵管炎。在206例CBFP反应患者中，35例患者接受了5年随访。这些患者中有26例初始RPR滴度为1：1，35例患者中有8例初始RPR滴度为1：2，35例患者中有1例初始RPR滴度为1：4。30例受试者的RPR血清逆转。我们认为，使用大样本人群进行的额外CBFP研究将有助于识别与梅毒无关的其他潜在严重疾病。这些结果可能有助于这些疾病的预测和诊断。(c)2014爱思唯尔有限公司版权所有。
To characterize the CBFP reaction in the modem era, we analyzed the results of parallel rapid plasma reagin (RPR) and Treponema pallidum particle agglutination (TPPA) tests from a total of 63,765 blood samples obtained at Zhongshan Hospital in the Medical College of Xiamen University from May 2008 to February 2013. Among the 63,765 tested blood samples, 206 (0.32%) had the CBFP reaction. In multivariate analysis, an increased likelihood of the CBFP reaction was associated with female subjects, subjects >= 2.80 years old, and subjects between 16 and 35 years old (P < 0.05). The CBFP reaction occurred in association with 17 categories of disease, including 60 types of diseases, in the 206 subjects. To our knowledge, a number of these diseases had not been previously reported to be associated with the CBFP in the RPR test, including false labor, megaloblastic anemias, aplastic anemias, redundant prepuce, congenital malformation of heart, and salpingitis. Among the 206 patients with the CBFP reaction, 35 patients were subjected to follow-up for five years. 26 out of 35 these patients were at a 1:1 initial RPR titer, 8 out of 35 patients were at a 1:2 initial RPR titer, and 1 out of 35 patients were at a 1:4 initial RPR titer. 30 subjects had their RPR seroreverted. In our opinion, additional CBFP research using a large sample population will contribute to the identification of additional underlying serious disorders that are not related to syphilis. Such results could be useful for the prediction and diagnosis of these diseases. (c) 2014 Elsevier B.V. All rights reserved.