Increased attention to spatial context increases both place field stability and spatial memory
Increased attention to spatial context increases both place field stability and spatial memory
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DOI：
10.1016/s0896-6273(04)00192-8
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发表时间：
2004-04-22
期刊：
影响因子：
16.2
通讯作者：
Kandel, ER
中科院分区：
文献类型：
--
作者：
Kentros, CG;Agnihotri, NT;Kandel, ER
海马体的形成对记忆的获取和巩固至关重要。当记录在自由运动的动物身上时，海马锥体神经元以特定位置的方式放电：它们是“位置”细胞，构成了动物环境的海马表征。为了探索位置细胞与空间记忆之间的关系，我们记录了小鼠在几种行为环境下的行为。我们发现位置细胞放电场的长期稳定性与注意需求的程度有关，而成功的空间任务表现与稳定的位置场有关。此外，最大化位置场稳定性的条件大大增加了对新线索的取向。这表明位置细胞的储存和提取是由自上而下的认知过程调节的，类似于注意力，并且位置细胞是空间记忆的神经相关细胞。我们提出了一个模型，即注意力提供了必要的神经调节，将短期同突触可塑性转换为长期异突触可塑性，我们暗示多巴胺在这一过程中。
The hippocampal formation is critical for the acquisition and consolidation of memories. When recorded in freely moving animals, hippocampal pyramidal neurons fire in a location-specific manner: they are "place" cells, comprising a hippocampal representation of the animal's environment. To explore the relationship between place cells and spatial memory, we recorded from mice in several behavioral contexts. We found that long-term stability of place cell firing fields correlates with the degree of attentional demands and that successful spatial task performance was associated with stable place fields. Furthermore, conditions that maximize place field stability greatly increase orientation to novel cues. This suggests that storage and retrieval of place cells is modulated by a top-down cognitive process resembling attention and that place cells are neural correlates of spatial memory. We propose a model whereby attention provides the requisite neuromodulatation to switch short-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in this process.