The role of ghrelin in energy homeostasis and its potential clinical relevance (Review)
The role of ghrelin in energy homeostasis and its potential clinical relevance (Review)
复制标题
DOI：
10.3892/ijmm_00000524
复制
发表时间：
2010-12-01
影响因子：
5.4
通讯作者：
Inui, Akio
中科院分区：
文献类型：
--
作者：
Cheng, Kai-Chun;Li, Ying-Xiao;Inui, Akio
新的胃激素Ghrelin是一种由28个氨基酸组成的多肽，已被证实是一种强大的生长激素促分泌剂。Ghrelin的产生受营养和激素因素的调节。研究表明，Ghrelin除了刺激生长激素的分泌外，还具有许多中枢和外周作用，如调节食物摄入量、控制能量平衡、葡萄糖代谢和胰岛素释放、心血管作用、刺激胃酸分泌和运动。与Ghrelin相关的广泛生物学活动范围继续扩大。未来，Ghrelin的多种功能为其在多种病理条件下的临床应用提供了可能性。
The novel gastric hormone ghrelin, a 28-amino acid peptide, has been identified as a potent growth-hormone secretagogue. Ghrelin production is regulated by nutritional and hormonal factors. Besides stimulating growth hormone secretion, studies show that ghrelin exerts a number of central and peripheral actions such as the regulation of food intake, the control of energy balance, glucose metabolism and insulin release, cardiovascular actions, the stimulation of gastric acid secretion, and motility. The broad spectrum of biological activities associated with ghrelin continues to expand. In the future, the diverse functions of ghrelin raise the possibility of its clinical application in a large number of pathological conditions.