Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages
Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages
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DOI：
10.1309/bg5va8jrdqh1m7hn
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发表时间：
2004-09-01
影响因子：
3.5
通讯作者：
Laman, JD
中科院分区：
文献类型：
--
作者：
Boven, LA;van Meurs, M;Laman, JD
Although the existence of anti-inflammatory alternatively activated macrophages (aamphi) has been accepted widely based on in vitro studies, their in. vivo location, phenotype, and function still are debated. Gaucher disease (GD) is caused by a genetic deficiency in the lysosomal enzyme glucocerebrosidase and is characterized by accumulation of glycosphingolipids in so-called Gaucher cells (GO). By using immunohistochemical analysis we investigated whether this results in an aamphiphenotype. GCs are macrophage-like cells, expressing acid phosphatase, CD68, CD14, and HLA class II, but not CD11b, CD40, or dendritic cell markers. GCs show infrequent immunoreactivity for mannose receptor: GCs did not express proinflammatory cytokines such as tumor necrosis factor alpha and monocyte chemoattractant protein 1, but did express the aamphi markers CD163, CCL18, and interleukin-1 receptor antagonist. Furthermore. CD36 and signal receptor protein. alpha, involved in lipid uptake, also were observed on GCs. Thus, GCs represent a distinctive population of myeloid cells that resemble aamphi but differ from previously described in vitro aamphi.
