Mechanisms of memory impairment in animal models of nontraumatic intracranial hemorrhage: A systematic review of the literature.
Mechanisms of memory impairment in animal models of nontraumatic intracranial hemorrhage: A systematic review of the literature.
复制标题
DOI：
10.1016/j.hest.2021.08.002
复制
发表时间：
2022-06
影响因子：
--
通讯作者：
Waldau, Ben
中科院分区：
文献类型：
--
作者：
Peterson, Catherine;Umoye, Alexis O.;Puglisi, Chloe H.;Waldau, Ben
关键词：
自发性颅内出血后记忆和认知功能障碍的机制是多种多样的。本系统综述的目的是对非创伤性颅内出血后记忆障碍的常见机制进行当代综述。系统检索PubMed、Embase和Scopus数据库中的临床前研究，并根据PRISMA指南报告结果。根据SYRCLE的偏倚风险工具进行方法学质量评估。90项研究符合纳入标准。大多数动物研究报告了蛛网膜下腔出血（48%），其次是脑实质内出血（44%）和脑室内出血（8%）。大多数蛛网膜下腔出血研究（30%）报告神经元凋亡是记忆功能障碍的一种机制，而脑实质内出血（40%）和脑室内出血（23%）后最常见的机制是促炎反应。根据SYRCLE的偏倚风险评估，所有研究的偏倚平均方法学风险为56.83 ± 12.77%（0 - 100%量表）。不仅需要更多的临床前研究，而且需要报告负面治疗效果的研究和多中心动物研究。对非啮齿类动物ICH模型的体内研究也可能有所帮助。
Mechanisms underlying memory and cognitive dysfunction following spontaneous intracranial hemorrhage are diverse. The aim of this systematic review was to provide a contemporary review of the commonly reported mechanisms responsible for memory impairment following nontraumatic intracranial hemorrhage. PubMed, Embase, and Scopus databases were systematically searched for pre-clinical studies, and results were reported according to PRISMA guidelines. Methodological quality assessment was performed according to the SYRCLE’s Risk of Bias tool. Ninety studies met the inclusion criteria. Most of animal studies reported on subarachnoid hemorrhage (48%), followed by intraparenchymal hemorrhage (44%), and intraventricular hemorrhage (8%). Most of subarachnoid hemorrhage studies (30%) reported neuronal apoptosis as a mechanism for memory dysfunction, whereas the most commonly described mechanism following intraparenchymal hemorrhage (40%) and intraventricular hemorrhage (23%) was a proinflammatory response. Based on SYRCLE’s Risk of Bias assessment, the average methodological risk of bias of all studies was 56.83 ± 12.77% on a 0–100% scale. There is a great need not only for more preclinical studies with improved methodology, but also for studies reporting negative treatment effects and for multicenter animal studies. In vivo studies on non-rodent animal ICH models can also be helpful.
登录
查看更多内容
肢体远程缺血后处理可减少蛛网膜下腔出血后大鼠的损伤并改善长期行为恢复：可能涉及自噬过程
影响因子：
3.4
作者：
Hu X;Lv T;Yang SF;Zhang XH;Miao YF
通讯作者：
Miao YF
影响因子：
38.9
作者：
Badri, Shide;Chen, Jasper;Treggiari, Miriam M.
通讯作者：
Treggiari, Miriam M.
影响因子：
6.9
作者：
Conzen, Catharina;Becker, Katrin;Schubert, Gerrit A.
通讯作者：
Schubert, Gerrit A.
头孢曲松通过 PI3K/AKT/NF-kappa B 信号通路增加兴奋性氨基酸转运蛋白 2 的表达，减轻蛛网膜下腔出血后的早期脑损伤
影响因子：
3.3
作者：
Feng, D.;Wang, W.;Qin, H.
通讯作者：
Qin, H.
影响因子：
5.3
作者：
Duan, Hongzhou;Li, Liang;Zhang, Jiayong
通讯作者：
Zhang, Jiayong