A case of concurrent anti-laminin γ1 pemphigoid and anti-laminin 332-type mucous membrane pemphigoid

A case of concurrent anti-laminin γ1 pemphigoid and anti-laminin 332-type mucous membrane pemphigoid
复制标题

抗层粘连蛋白γ1型类天疱疮与抗层粘连蛋白332型粘膜类天疱疮并发1例

DOI：
10.1111/bjd.13113
复制
发表时间：
2014
期刊：
Br J Dermatol
影响因子：
--
通讯作者：
and Hashimoto T
and Hashimoto T
中科院分区：
--
文献类型：
--
作者：
Li X;Qian H;Ishii N;Yamaya M;Fukuda H;Mukai H;Hirako Y;and Hashimoto T

文献摘要

相似文献

亲爱的编辑，粘膜类天疱疮（MMP）表现为各种粘膜病变，特别是沿着牙龈上的牙齿沿着出现天鹅绒般的糜烂。直接免疫荧光显示IgG和/或伊加沉积在基底膜区（BMZ）。1在间接免疫荧光中，70-80%的MMP血清中的IgG和/或伊加抗体与1 mol Là 1 NaCl-分裂皮肤的表皮侧反应，而IgG抗体与大约20%的MMP血清中的真皮侧反应。与表皮侧反应的IgG和/或伊加抗体与BP 180 C末端结构域的重组蛋白（RP）（抗BP 180型MMP）反应。3-5与皮肤侧反应的IgG抗体与层粘连蛋白-332（抗层粘连蛋白-332-型MMP）反应。6抗BP 180型MMP通常仅显示口腔病变，而抗层粘连蛋白332型MMP倾向于发展严重的眼和喉病变。1此外，先前的研究报道，在眼和口腔MMP中分别检测到针对整合素a6 b4的b4和a6亚基的IgG抗体。因此，MMP是非常异质的，这使得诊断困难。本研究报告了一个病人的口腔MMP与IgG自身抗体的b4和a6亚基的整合素a6 b4。
DEAR EDITOR, Mucous membrane pemphigoid (MMP) presents various mucosal lesions, particularly velvety erythematous erosions along the teeth on the gingivae. 1, 2 Direct immunofluorescence reveals IgG and/or IgA deposits to the basement membrane zone (BMZ). 1 In indirect immunofluorescence, IgG and/or IgA antibodies in 70–80% of MMP sera react with the epidermal side of 1 mol Là1 NaCl-split skin, while IgG antibodies react with the dermal side in approximately 20% of MMP sera.In immunoblotting, IgG and/or IgA antibodies reactive with the epidermal side react with recombinant protein (RP) of the BP180 C-terminal domain (anti-BP180-type MMP). 3–5 IgG antibodies reactive with the dermal side react with laminin-332 (antilaminin-332-type MMP). 6 While anti-BP180-type MMP usually shows only oral lesions, antilaminin-332-type MMP tends to develop severe ocular and laryngeal lesions. 1 In addition, previous studies reported that IgG antibodies to the b4 and a6 subunits of integrin a6b4 were detected in ocular and oral MMP, respectively. 7, 8 Thus, MMP is extremely heterogeneous, which makes diagnosis difficult. This study reports a patient with oral MMP with IgG autoantibodies to both the b4 and a6 subunits of integrin a6b4.