A convenient synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by rhodium-catalyzed intramolecular hydroamidation
A convenient synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by rhodium-catalyzed intramolecular hydroamidation
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DOI：
10.1016/j.tetlet.2005.08.133
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发表时间：
2005-10-31
影响因子：
1.8
通讯作者：
Takemoto, Y
中科院分区：
文献类型：
--
作者：
Kobayashi, Y;Kamisaki, H;Takemoto, Y
研究了铑催化的羰基环合反应。在Rh-4（CO）（12）存在下，各种具有炔基的甲酰胺的环化顺利进行，以中等至良好的产率和高（E）-选择性提供α-亚烷基-γ-内酰胺或3-亚烷基羟吲哚。(c)2005爱思唯尔有限公司保留所有权利。
Rhodium-catalyzed carbonylative cyclization without carbon monoxide was investigated. Cyclization of various form-amides having alkynyl groups proceeded smoothly in the presence of Rh-4(CO)(12) to provide alpha-alkylidene-gamma-lactams or 3-alkylideneoxindoles in moderate to good yields with high (E)-selectivity. (c) 2005 Elsevier Ltd. All rights reserved.