Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
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DOI：
10.1002/gcc.10198
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发表时间：
2003-06-01
影响因子：
3.7
通讯作者：
Young, BD
中科院分区：
文献类型：
--
作者：
Debernardi, S;Lillington, DM;Young, BD
对28例急性髓系白血病（AML）患者的外周血和骨髓标本进行基因表达谱测定。分层聚类将谱分类到单独的组中，每组代表AML中的主要细胞遗传学类别之一[即，t（8;21）、t（15; 17）、inv（16）、11 q23和正常核型]。统计组比较确定的基因，其表达与这些染色体类强烈相关。此外，正常核型AML的特征是I类同源框A和B基因家族的某些成员的独特上调，这意味着共同的潜在遗传病变。这些数据揭示了新的诊断和治疗靶点，并证明了基于微阵列的AML解剖的潜力。(C)2003 Wiley-Liss，Inc.
Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML). Hierarchical clustering sorted the profiles into separate groups, each representing one of the major cytogenetic classes in AML [i.e., t(8;21), t(15; 17), inv(16), 11q23, and normal karyotype]. Statistical group comparison identified genes whose expression was strongly correlated with these chromosomal classes. Moreover, the normal karyotype AMLs were characterized by distinctive up-regulation of certain members of the class I homeobox A and B gene families, implying a common underlying genetic lesion. These data reveal novel diagnostic and therapeutic targets and demonstrate the potential of microarray-based dissection of AML. (C) 2003 Wiley-Liss, Inc.