Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females
Effects of sex steroid deprivation/administration on hair growth and skin sebum production in transsexual males and females
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DOI：
10.1210/jc.85.8.2913
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发表时间：
2000-08-01
影响因子：
5.8
通讯作者：
Gooren, LJG
中科院分区：
文献类型：
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作者：
Giltay, EJ;Gooren, LJG
为了研究雄激素对皮肤毛囊皮脂腺单位的影响，我们研究了 21 名男性变女性的变性者和 17 名接受变性激素的女性变男性的变性者。在基线以及 4、8 和 12 个月后，通过 Ferriman-Gallwey 评分评估毛发生长情况；利兹痤疮分类；通过图像分析获得毛发生长速率、密度和轴直径；以及 Sebutape 的皮脂产生。在男性中，雌激素和抗雄激素将血浆睾酮降低至 1.0 nmoL/L 以下。尽管毛发生长和皮脂产生的所有参数均下降，但面部毛发仍在生长。 4个月后，毛干直径的减小达到最大，并且似乎与毛发生长长度和密度的变化呈负相关。对于女性来说，睾酮会增加头发的生长速度和皮脂的产生。 12个月后，脸颊和腹部的毛发还没有达到雄性的直径。 5 α -Androstane-3 α,17 β -二醇葡萄糖醛酸水平与毛发生长和皮脂产生只有微弱的相关性。总之，雌激素和抗雄激素的施用以不同的速率影响毛发的长度和直径。在几乎没有雄激素的情况下，头发会继续生长，但速度会减慢。女性在服用雄激素12个月后，头发直径还没有达到成年男性的数值。
To investigate androgen effects on the skin pilosebaceous unit, we studied 21 male-to-female transsexuals and 17 female-to-male transsexuals receiving cross-sex hormones. At baseline and after 4, 8, and 12 months, hair growth was evaluated by the Ferriman-Gallwey score; acne by the Leeds classification; hair growth rate, density, and shaft diameter by image analysis; and sebum production by Sebutape. In males, estrogens and antiandrogens reduced plasma testosterone to below 1.0 nmoL/L. Though all parameters of hair growth and sebum production declined, facial hair growth continued. After 4 months, the decrease in shaft diameter had reached its maximum and seemed inversely associated with changes in hair growth length and density. In females, testosterone increased hair growth rate and sebum production. After 12 months, hairs on the cheek and abdomen had not yet reached diameters found in males. 5 alpha -Androstane-3 alpha ,17 beta -diol glucuronide levels were only weakly associated with hair growth and sebum production. In conclusion, administration of estrogens and antiandrogens affects length and diameter of hairs at different rates. In the virtual absence of androgens, hair growth continues but at a slower rate. In women, after 12 months of androgen administration, hair diameters have not reached values of adult men.