The adrenal gland is a source of stress-induced circulating IL-18
The adrenal gland is a source of stress-induced circulating IL-18
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DOI：
10.1016/j.jneuroim.2005.11.001
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Conti, B
中科院分区：
文献类型：
--
作者：
Sugama, S;Wang, N;Conti, B
本研究比较了应激后假手术和肾上腺切除小鼠的血浆IL-18水平，以研究肾上腺是否有助于应激期间循环IL-18的升高。两个小时的应激刺激了假手术小鼠肾上腺中IL-18 mRNA和肽的强烈的、应激依赖性的升高。一致地，循环成熟IL-18的水平在应激期间增加，并且在应激后保持升高长达6小时。应激诱导的循环IL-18的增加被肾上腺切除术消除。这些发现表明，在应激期间需要肾上腺来实现循环IL-18的升高。(C)2005 Elsevier B. V.保留所有权利。
The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy, These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress. (C) 2005 Elsevier B.V. All rights reserved.