The efficiency of functional brain networks does not differ between smokers and non-smokers
The efficiency of functional brain networks does not differ between smokers and non-smokers
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DOI：
10.1016/j.pscychresns.2013.07.005
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发表时间：
2013-12-30
影响因子：
2.3
通讯作者：
Giessing, Carsten
中科院分区：
文献类型：
--
作者：
Breckel, Thomas Peer Karl;Thiel, Christiane Margarethe;Giessing, Carsten
吸烟者的急性尼古丁摄入对大脑网络的功能拓扑结构产生影响，表明信息传输效率和注意任务表现都有所提高。长期摄入尼古丁对功能性大脑网络拓扑结构的影响尚不清楚。我们在这里研究了慢性吸烟行为对脑功能网络拓扑结构的影响。轻度剥夺吸烟者(N=18)和不吸烟者(N=17)在静息状态下用功能磁共振扫描仪进行测量。在两组中比较了已被证明受急性尼古丁注射影响的功能网络整合(全球效率和集群)的图论指标。我们的结果显示，吸烟状态并没有显著改变功能网络整合。非劣性的附加测试证实了区域或节点网络属性的相似性。大脑区域，如左侧岛状回和额叶中回，急性尼古丁摄入影响了网络拓扑结构，但没有显示出慢性尼古丁摄入后功能网络效率的任何下降。在调查样本量的限制下，我们的数据表明，在最低限度剥夺吸烟者中，大脑功能网络的整合没有改变。我们的发现与临床研究有关，这些研究表明吸烟高发的精神病患者和健康对照组之间的网络拓扑结构发生了变化。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Acute nicotine consumption in smokers impacts on functional brain network topology indicating an increase in the efficiency of information transfer and attentional task performance. The effects of chronic nicotine consumption on functional brain network topology are unknown. We here investigated the effects of chronic smoking-behaviour on functional brain network topology. Minimally-deprived smokers (N=18) and non-smokers (N=17) were measured within an fMRI scanner during a resting state condition. Graph-theoretical metrics of functional network integration (global efficiency and clustering) that have been shown to be affected by acute nicotine administration were compared between both groups. Our results revealed that smoking status did not significantly change functional network integration. Additional tests for non-inferiority confirmed the similarity of regional or nodal network properties. Brain regions such as the left insular and middle frontal gyms, in which acute nicotine consumption affected network topology, did not reveal any decrease in functional network efficiency following chronic nicotine consumption. Within the limitation of the investigated sample size, our data suggest that the integration of functional brain networks is not altered in minimally-deprived smokers. Our findings are of relevance for clinical studies showing changes in network topology between psychiatric patients with high prevalence of smoking and healthy control subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.