Organophotocatalytic Regioselective C-H Alkylation of Electron-Rich Arenes Using Activated and Unactivated Alkenes
Organophotocatalytic Regioselective C-H Alkylation of Electron-Rich Arenes Using Activated and Unactivated Alkenes
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DOI：
10.1002/anie.202200773
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发表时间：
2022-04-05
影响因子：
16.6
通讯作者：
Shu, Wei
中科院分区：
文献类型：
--
作者：
Chen, Bi-Hong;Du, Yi-Dan;Shu, Wei
以选择性的方式直接烷基化碳氢键芳烃是一个长期的挑战。本文研究了一种富电子芳烃与活化和未活化烯烃的无金属光催化区域选择性C-H烷基化方法。该反应适用于具有不同取代模式的各种芳香环，以及端烯烃和内烯烃，为惰性碳氢键形成C-C键提供了一种通用且直接的无金属方法。此外，炔烃还可与富电子芳烃的C-H乙烯化反应相容。
Direct alkylation of the C-H bond arenes in a selective manner is a long-standing challenge. Herein, a metal-free photocatalytic regioselective C-H alkylation method for electron-rich arenes with both activated and unactivated alkenes was developed. The reaction tolerates a wide range of aromatic rings with diverse substitution patterns, as well as terminal and internal alkenes, providing a general and straightforward metalfree method for C-C bond formation from inert C-H bonds. Moreover, alkynes are also compatible to give the C-H vinylation of electron-rich arenes.