In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee.
In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee.
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DOI：
10.1038/srep19220
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发表时间：
2016-01-11
影响因子：
4.6
通讯作者：
Neu CP
中科院分区：
文献类型：
--
作者：
Chan DD;Cai L;Butz KD;Trippel SB;Nauman EA;Neu CP
关节软骨变形的活体测量对于了解机械力如何在健康组织中分布以及病理性关节中随时间的变化是至关重要的。移位或应变可以作为健康、病变和修复组织的功能成像生物标志物，但不幸的是，活体软骨内变形在很大程度上是未知的。在这里，我们首次通过测量健康志愿者的胫股关节软骨厚度来直接量化变形模式。磁共振成像采集与生理相关的压缩载荷同步，用于显示和测量胫股关节软骨在矢状面上的局部位移和应变。我们发现，在足部施加压力(体重的1/2)会在胫股软骨交界处产生滑动的刚体位移，负荷会产生特定对象和性别的局部复杂的关节内应变模式，而主要的软骨应变(接近12%)是剪切的。胫骨的最大值原理和剪切应变测量值与体重指数相关。我们基于MRI的方法可能会加速疾病或受损软骨的再生治疗的发展，目前缺乏可靠的体内方法来非侵入性评估治疗后的功能变化。
The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the pathologic joint. Displacements or strain may serve as a functional imaging biomarker for healthy, diseased, and repaired tissues, but unfortunately intratissue cartilage deformation in vivo is largely unknown. Here, we directly quantified for the first time deformation patterns through the thickness of tibiofemoral articular cartilage in healthy human volunteers. Magnetic resonance imaging acquisitions were synchronized with physiologically relevant compressive loading and used to visualize and measure regional displacement and strain of tibiofemoral articular cartilage in a sagittal plane. We found that compression (of 1/2 body weight) applied at the foot produced a sliding, rigid-body displacement at the tibiofemoral cartilage interface, that loading generated subject- and gender-specific and regionally complex patterns of intratissue strains, and that dominant cartilage strains (approaching 12%) were in shear. Maximum principle and shear strain measures in the tibia were correlated with body mass index. Our MRI-based approach may accelerate the development of regenerative therapies for diseased or damaged cartilage, which is currently limited by the lack of reliable in vivo methods for noninvasive assessment of functional changes following treatment.