T-HELPER CELL SUBSETS IN INSULIN-DEPENDENT DIABETES
T-HELPER CELL SUBSETS IN INSULIN-DEPENDENT DIABETES
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DOI：
10.1126/science.7761837
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发表时间：
1995-05-26
期刊：
影响因子：
56.9
通讯作者：
MATHIS, D
中科院分区：
文献类型：
--
作者：
KATZ, JD;BENOIST, C;MATHIS, D
已经提出胰岛素依赖型糖尿病的发展是由自身反应性T-H细胞的T辅助细胞1（T（H）1）与T（H）2表型控制的：T（H）1细胞会促进糖尿病，而T（H）2细胞实际上会保护免于疾病。通过建立表达相同致糖尿病T细胞受体的T（H）1和T（H）2细胞培养物，并比较它们在新生非肥胖糖尿病小鼠中引发疾病的能力，来验证这一命题。T（H）1样细胞积极促进糖尿病; T（H）2样细胞侵入胰岛，但不引起疾病，也不提供实质性保护。
It has been proposed that the development of insulin-dependent diabetes is controlled by the T helper 1 (T(H)1) versus T(H)2 phenotype of autoreactive T-H cells: T(H)1 cells would promote diabetes, whereas, T(H)2 cells would actually protect from disease. This proposition was tested by establishing cultures of T(H)1 and T(H)2 cells that express and identical diabetogenic T cell receptor and comparing their ability to initiate disease in neonatal nonobese diabetic mice. T(H)1-like cells actively promoted diabetes; T(H)2-like cells invaded the islets but did not provoke disease-neither did they provide substantial protection.