Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis
Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis
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DOI：
10.1016/j.diabres.2014.08.010
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发表时间：
2014-11-01
影响因子：
5.1
通讯作者：
Kengne, Andre P.
中科院分区：
文献类型：
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作者：
Balti, Eric V.;Echouffo-Tcheugui, Justin B.;Kengne, Andre P.
目的：暴露在相对高水平的空气污染中是否与糖尿病的发生有关尚不清楚。我们试图评估和量化暴露于主要空气污染物与2型糖尿病风险之间的关系。方法：检索PubMed和EMBASE数据库（截至2013年9月），使用与暴露于气态（NO2和NOx）或颗粒物污染物（PM2.5， PM10和PM10-2.5）和2型糖尿病相关的术语组合进行检索。从选定的研究中提取描述性和定量信息。我们使用随机效应模型荟萃分析来得出每种污染物的总体风险估计。结果：我们纳入了10项研究（5项横断面研究和5项前瞻性研究），评估了空气污染物对糖尿病发生的影响。在前瞻性调查中，NO2（校正风险比[HR]为1.13；95%可信区间[95% ci]为1.01-1.22;p < 0.001; I-2 = 36.4%, p（异质性）= 0.208）和PM2.5 （HR为1.11；95% ci为1.03-1.20;p < 0.001; I-2 = 0.0%，异质性= 0.827）对糖尿病发生的总体影响均显著。两项横断面研究报告了比值比，揭示了二氧化氮和PM2.5与2型糖尿病之间的相似关联。在所有研究中，风险估计通常会根据年龄、性别、体重指数和吸烟情况进行调整。结论：现有证据支持主要空气污染物与2型糖尿病风险增加的潜在关联。这一发现可能会对以人群为基础的降低糖尿病风险的策略产生影响。2014爱思唯尔爱尔兰有限公司版权所有。
Aim: Whether exposure to relatively high levels of air pollution is associated with diabetes occurrence remains unclear. We sought to assess and quantify the association between exposure to major air pollutants and risk of type 2 diabetes.Methods: PubMed and EMBASE databases (through September 2013) were searched using a combination of terms related to exposure to gaseous (NO2 and NOx) or particulate matter pollutants (PM2.5, PM10 and PM10-2.5) and type 2 diabetes. Descriptive and quantitative information were extracted from selected studies. We used random-effects models meta-analysis to derive overall risk estimates per type of pollutant.Results: We included ten studies (five cross-sectional and five prospective), assessing the effects of air pollutants on the occurrence of diabetes. In prospective investigations, the overall effect on diabetes occurrence was significant for both NO2 (adjusted hazard ratio [HR], 1.13; 95% confidence interval [95%CI], 1.01-1.22; p < 0.001; I-2 = 36.4%, p(heterogeneity) = 0.208) and PM2.5 (HR, 1.11; 95%CI, 1.03-1.20; p < 0.001; I-2 = 0.0%, pheterogeneity = 0.827). Odds ratios were reported by two cross-sectional studies which revealed similar associations between both NO2 and PM2.5 with type 2 diabetes. Across studies, risk estimates were generally adjusted for age, gender, body mass index and cigarette smoking.Conclusions: Available evidence supports a prospective association of main air pollutants with an increased risk for type 2 diabetes. This finding may have implications for population-based strategies to reduce diabetes risk. (C) 2014 Elsevier Ireland Ltd. All rights reserved.