Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins
Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins
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N-乙酰氨基葡萄糖三萜皂苷的合成及其细胞毒活性
DOI：
10.1016/j.carres.2010.01.002
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发表时间：
2010-03-30
影响因子：
3.1
通讯作者：
Li, Yingxia
中科院分区：
文献类型：
--
作者：
Wang, Peng;Wang, Jun;Li, Yingxia
合成了14个含有N-乙酰-β-D-氨基葡萄糖的熊果酸和齐墩果酸皂苷，以及(1>；4)和(16)-连接的N-乙酰-β-D-氨基葡萄糖低聚糖残基。所有化合物的结构均经~(1)H、~(13)C核磁共振谱和质谱学确证，并测定了它们对三种癌细胞的细胞毒活性。只有齐墩果酸-3-基β-D-GluNAc对HL-60和BGC-823有明显的细胞毒作用。(C)2010年由爱思唯尔有限公司出版。
Fourteen ursolic acid and oleanolic acid saponins with N-acetyl-beta-D-glucosamine, and (1 -> 4)-linked and (1 6)-linked N-acetyl-beta-D-glucosamine oligosaccharide residues were synthesized in a convergent manner. The structures of all compounds were confirmed by (1)H NMR and (13)C NMR spectroscopy and by mass spectrometry, and their cytotoxic activities were assayed in three cancer cell lines. Only oleanolic acid-3-yl beta-D-GluNAc showed significant cytotoxicity against HL-60 and BGC-823. (C) 2010 Published by Elsevier Ltd.