Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization.
Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization.
复制标题
神经嵴源性肿瘤中的神经肽 Y：对生长和血管化的影响。
DOI：
10.1016/j.canlet.2006.01.010
复制
发表时间：
2007
期刊：
影响因子：
9.7
通讯作者：
Kitlinska,Joanna
中科院分区：
文献类型：
--
作者：
Kitlinska,Joanna
神经肽Y（neuropeptide Y，NPY）是一种交感神经递质，近年来被发现是一种强有力的促生长和促血管生成因子。该肽及其受体在神经嵴来源的肿瘤中是丰富的，例如交感神经母细胞瘤和嗜铬细胞瘤，以及副交感神经尤文氏肉瘤家族肿瘤。NPY通过自分泌激活肿瘤细胞增殖或凋亡直接调节其生长，并通过其血管生成活性间接调节其生长。肽对肿瘤生长的总体作用取决于这些过程与肿瘤细胞中表达的受体类型之间的平衡。因此，NPY及其受体可能成为治疗神经肿瘤的靶点，直接针对肿瘤细胞增殖和血管生成。
Neuropeptide Y (NPY) is a sympathetic neurotransmitter recently found to be a potent growth and angiogenic factor. The peptide and its receptors are abundant in neural crest-derived tumors, such as sympathetic neuroblastomas and pheochromocytomas, as well as parasympathetic Ewing's sarcoma family of tumors. NPY regulates their growth directly, by an autocrine activation of tumor cell proliferation or apoptosis, and indirectly, by its angiogenic activity. The overall effect of the peptide on tumor growth depends on a balance between these processes and the type of receptors expressed in the tumor cells. Thus, NPY and its receptors may become targets for the treatment of neural tumors, directed against both tumor cell proliferation and angiogenesis.