Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation.
Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation.
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DOI：
10.1177/0022034515624444
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发表时间：
2016-03-01
影响因子：
--
通讯作者：
Schwartz, Z
中科院分区：
文献类型：
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作者：
Boyan, B D;Cheng, A;Schwartz, Z
牙种植体材料、结构设计和表面性质的变化都可能影响生物反应。虽然整体性能对种植体的机械稳定性很重要，但表面设计最终有助于骨整合。本文综述了有助于改善细胞反应和骨整合的牙科种植体材料的表面参数。特别是，我们专注于表面设计如何影响间充质细胞的反应和分化成骨细胞谱系。表面粗糙度已经在很大程度上在微观尺度上进行了研究，但最近的研究已经强调了分级微米/亚微米/纳米表面粗糙度的重要性，以及表面粗糙度与表面润湿性的结合。整合素是识别表面变化并介导下游信号传导途径的跨膜受体。具体而言，非经典的Wnt 5a途径已涉及钛植入物表面上的细胞的成骨细胞分化。然而，仍有许多问题有待澄清。仅在最近才进行了基于性别、年龄和临床因素的植入物生物学反应差异研究;这些都指向提倡患者特定植入物设计的差异。最后，必须解决植入物表面表征的挑战，以优化和比较研究数据。对材料的科学和生物学的理解对于开发新型牙科种植体材料和表面改性以改善骨整合至关重要。
Changes in dental implant materials, structural design, and surface properties can all affect biological response. While bulk properties are important for mechanical stability of the implant, surface design ultimately contributes to osseointegration. This article reviews the surface parameters of dental implant materials that contribute to improved cell response and osseointegration. In particular, we focus on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage. Surface roughness has been largely studied at the microscale, but recent studies have highlighted the importance of hierarchical micron/submicron/nanosurface roughness, as well as surface roughness in combination with surface wettability. Integrins are transmembrane receptors that recognize changes in the surface and mediate downstream signaling pathways. Specifically, the noncanonical Wnt5a pathway has been implicated in osteoblastic differentiation of cells on titanium implant surfaces. However, much remains to be elucidated. Only recently have studies been conducted on the differences in biological response to implants based on sex, age, and clinical factors; these all point toward differences that advocate for patient-specific implant design. Finally, challenges in implant surface characterization must be addressed to optimize and compare data across studies. An understanding of both the science and the biology of the materials is crucial for developing novel dental implant materials and surface modifications for improved osseointegration.