Thalamic ablations and neocortical development: alterations of cortical cytoarchitecture and cell number.
Thalamic ablations and neocortical development: alterations of cortical cytoarchitecture and cell number.
复制标题
丘脑消融和新皮质发育：皮质细胞结构和细胞数量的改变。
DOI：
10.1093/cercor/1.3.230
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Finlay,BL
中科院分区：
文献类型：
--
作者：
Windrem,MS;Finlay,BL
新皮层细胞结构的多样性可能源于脑室区细胞类型和数量的遗传预设，细胞与其直接环境、传出目标或传入输入的相互作用。在这里，我们研究的作用，丘脑作为传出目标或传入源的细胞数量和类型的早期控制在发展中的新皮层。在仓鼠出生前，丘脑IV层的神经支配的丘脑电解病变。到出生后第7天，当迁移到皮质是完整的，有没有差异，对侧和同侧的丘脑病变，表明丘脑输入的情况下，皮质板之间的细胞数量不影响新皮质细胞生成或迁移的最后阶段。然而，此时皮质板上半部分的固缩细胞发生率升高。到了成年期，皮质每单位柱的细胞数量减少，这是由于明显缺乏小的，非锥体细胞的第四层，从尼斯染色材料确定。因此，新皮层的一些细胞结构变异性可能是由新皮层细胞与其传入连接的相互作用引起的。
The diversity of neocortical cytoarchitecture could arise from genetic prespecification of cell types and numbers in the ventricular zone, by interaction of cells with their immediate environment, efferent targets, or afferent inputs. Here, we examine the role of the thalamus as efferent target or afferent source in the early control of cell number and type in the developing neocortex. Electrolytic lesions of the thalamus were made in hamsters at birth prior to the thalamic innervation of layer IV. By postnatal day 7, when migration to the cortex is complete, there were no differences in cell number between the cortical plate contralateral and ipsilateral to the thalamic lesion, showing that the absence of thalamic input does not influence the last phases of neocortical cell generation or migration. However, the incidence of pyknotic cells was elevated in the upper half of the cortical plate at this time. By adulthood, the number of cells per unit column of cortex was reduced, due to the apparent absence of small, nonpyramidal cells of layer IV, as determined from Nissl-stained material. Therefore, some of the cytoarchitectonic variability of the neocortex could arise epigenetically by the interaction of neocortical cells with their afferent connections.