Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc
Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc
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100Mo(γ,n)反应制备99Mo及99mTc的化学分离
DOI：
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发表时间：
2016
影响因子：
1.6
通讯作者：
A. Goswami
中科院分区：
文献类型：
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作者：
A. Gopalakrishna;H. Naik;S. Suryanarayana;Yogeshkumar S. Naik;V. Nimje;B. K. Nayak;S. Sarkar;S. Padmanabhan;C. Kothalkar;P. Naskar;A. Dey;A. Goswami
以天然钼化合物（三氧化钼和钼酸锆凝胶）为原料，用100Mo（γ, n）反应制备了放射性核素99Mo，其轫致辐射端点能分别为10和15 MeV。平衡后，99mTc作为NaTcO4从辐照样品中分离，使用两种不同的化学方法来检测化学产率。从ZrMo凝胶中分离得到的Na[99mTc]TcO4的99Mo突破<10−4%，放射化学纯度为bbb99 %， Al、Mo和Zr的化学杂质<10 ppm。99Mo和99mTc的测定采用离线γ射线谱技术。从溶解的三氧化钼中分离出99mTc的化学收率为70.7 ~ 75.2%，而从未溶解的钼酸锆凝胶中分离出99mTc的化学收率为19.1 ~ 43%。第二种方法更可取，因为它在整个保质期内对医院放射药学的用户友好。
The radionuclide 99Mo has been prepared by 100Mo(γ, n) reaction using two types of natural molybdenum compound (molybdenum trioxide and zirconium molybdate gel) with the bremsstrahlung end-point energies of 10 and 15 MeV. After the equilibrium, 99mTc was separated as NaTcO4 from the irradiated samples using two different chemical procedures to examine the chemical yield. The separated Na[99mTc]TcO4 from the ZrMo gel has the 99Mo breakthrough of <10−4 %, radiochemical purity >99 % as well as chemical impurities of Al, Mo and Zr < 10 ppm. The estimation of 99Mo and 99mTc was done by using off-line γ-ray spectrometric technique. The chemical yield of the separated 99mTc from the dissolved molybdenum trioxide is 70.7–75.2 %, whereas in the undissolved zirconium molybdate gel, it is 19.1–43 %. The second method is preferable because it is user friendly in hospital radiopharmacy throughout the shelf-life.