Single-molecule studies of classical and desmosomal cadherin adhesion
Single-molecule studies of classical and desmosomal cadherin adhesion
复制标题
DOI：
10.1016/j.cobme.2019.08.006
复制
发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Sivasankar, Sanjeevi
中科院分区：
文献类型：
--
作者：
Priest, Andrew Vae;Koirala, Ramesh;Sivasankar, Sanjeevi
经典钙粘蛋白和桥粒钙粘蛋白细胞-细胞粘附蛋白在组织形态发生和维持组织完整性中发挥重要作用。钙粘蛋白粘附缺陷是癌症、皮肤病和心肌病等疾病的标志。结构研究和单分子生物物理测量揭示了这些关键粘附蛋白之间的关键相似性和令人惊讶的差异。这篇综述总结了我们目前对经典和桥粒钙粘蛋白粘附的生物物理学及其相互影响的分子基础的理解。我们专注于最近的单分子测量，强调对钙粘蛋白细胞外区域的粘附及其与相关疾病的关系的关键见解，并确定这个令人兴奋的研究领域中的主要悬而未决的问题。
Classical cadherin and desmosomal cadherin cell-cell adhesion proteins play essential roles in tissue morphogenesis and in maintaining tissue integrity. Deficiencies in cadherin adhesion are hallmarks of diseases such as cancers, skin diseases, and cardiomyopathies. Structural studies and single-molecule biophysical measurements have revealed critical similarities and surprising differences between these key adhesion proteins. This review summarizes our current understanding of the biophysics of classical and desmosomal cadherin adhesion and the molecular basis for their cross talk. We focus on recent single-molecule measurements, highlight key insights into the adhesion of cadherin extracellular regions and their relation to associated diseases, and identify major open questions in this exciting area of research.