EFFECT OF VERY SMALL CONCENTRATIONS OF INSULIN ON FOREARM METABOLISM . PERSISTENCE OF ITS ACTION ON POTASSIUM + FREE FATTY ACIDS WITHOUT ITS EFFECT ON GLUCOSE
EFFECT OF VERY SMALL CONCENTRATIONS OF INSULIN ON FOREARM METABOLISM . PERSISTENCE OF ITS ACTION ON POTASSIUM + FREE FATTY ACIDS WITHOUT ITS EFFECT ON GLUCOSE
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DOI：
10.1172/jci104981
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发表时间：
1964-01-01
影响因子：
15.9
通讯作者：
RABINOWITZ, D
中科院分区：
文献类型：
--
作者：
ZIERLER, KL;RABINOWITZ, D
将胰岛素以1、10或100 [mu]U/min/kg体重的速率注入正常男性的肱动脉。最小剂量对前臂代谢没有可测量的影响。最大剂量产生的葡萄糖和钾的前臂和游离脂肪酸（FFA）从脂肪组织释放的封锁。中等剂量，这提高了肱动脉胰岛素浓度平均每毫升38 [mu]U显着增加钾摄取前臂肌肉和脂肪组织和急剧减少FFA从脂肪组织的释放。前臂（肌肉和脂肪组织）的葡萄糖摄取没有改变。结论是胰岛素对钾吸收和FFA释放的作用不需要胰岛素转运葡萄糖。
Insulin was infused into the brachial artery of normal men at a rate of either 1, 10 or 100 [mu]U/minute/kg body weight. The smallest dose was without measurable effect on forearm metabolism. The largest dose produced uptake of glucose and K by forearm and blockade of free fatty acid (FFA) release from adipose tissue. The intermediate dose, which raised brachial arterial insulin concentration by an average of 38 [mu]U per ml markedly increased K uptake by both forearm muscle and adipose tissue and sharply reduced FFA release from adipose tissue. Glucose uptake by forearm (muscle and adipose tissue) was not altered. It is concluded that insulin''s actions on K uptake and on FFA release do not require that insulin translocate glucose.