Adherence to Healthy Lifestyle and Liver cancer in Chinese: a prospective cohort study of 0.5 million people
Adherence to Healthy Lifestyle and Liver cancer in Chinese: a prospective cohort study of 0.5 million people
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中国人坚持健康生活方式与肝癌：50万人的前瞻性队列研究
DOI：
10.1038/s41416-021-01645-x
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发表时间：
2021-12-01
影响因子：
8.8
通讯作者：
Li, Liming
中科院分区：
文献类型：
--
作者：
Song, Ci;Lv, Jun;Li, Liming
背景：关于健康生活方式因素的组合是否与肝癌风险的显著降低有关，几乎没有前瞻性证据。方法基于前瞻性中国嘉道理生物样本库（CKB）队列，共492，640名中国成年人，我们研究了5种生活方式因素与肝癌风险的关系。低风险的生活方式因素被定义为不吸烟，不喝酒，中等或更高水平的体力活动，健康的饮食，以及男性的腰臀比（WHR）< 0.90。结果在中位数为10.12年的随访中，观察到2529例肝癌事件。随着健康生活方式指数得分的增加，肝癌的危险性显著降低（P < 0.001）。与生活方式不利（0或1个健康生活方式因素）的参与者相比，生活方式有利（4或5个健康生活方式因素）的参与者肝癌风险降低43%（HR，0.57 [95%CI，0.47-0.68]）。健康的生活方式对肝癌的累积保护作用似乎对B型肝炎表面抗原（HBsAg）阳性的肝癌高危人群更为显著。结论：坚持良好生活方式的个体与肝癌绝对风险的显著降低相关。
Background Little prospective evidence exists about whether a combination of healthy lifestyle factors is related to a considerable reduction of liver cancer risk. Methods Based on the prospective China Kadoorie Biobank (CKB) cohort with a total of 492,640 Chinese adults, we examined the associations of five lifestyle factors with risk of liver cancer. Low-risk lifestyle factors were defined as non-smoking, non-drinking, median or higher level of physical activity, a healthy diet, and waist-to-hip ratio (WHR) < 0.90 for men and Results During a median of 10.12 years of follow-up, 2529 liver cancer events were observed. There was a significant decrease in liver cancer risk with the increasing of the healthy lifestyle index scores (P < 0.001). Participants with a favourable lifestyle (4 or 5 healthy lifestyle factors) had a 43% reduced liver cancer risk compared with those with an unfavourable lifestyle (0 or 1 healthy lifestyle factor) (HR, 0.57 [95% CI, 0.47-0.68]). The cumulative protective effect of a healthy lifestyle on liver cancer appeared to be more dramatic for patients with hepatitis B surface antigen (HBsAg) positive, the individuals at high risk of liver cancer. Conclusions Individuals adhering to a favourable lifestyle was associated with a considerable absolute risk reduction of liver cancer.