Presence of 20% or more clue cells: An accurate criterion for the diagnosis of bacterial vaginosis in Papanicolaou cervical smears
Presence of 20% or more clue cells: An accurate criterion for the diagnosis of bacterial vaginosis in Papanicolaou cervical smears
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DOI：
10.1002/dc.20418
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发表时间：
2006-04-01
影响因子：
1.3
通讯作者：
Montemor, EBL
中科院分区：
文献类型：
--
作者：
Discacciati, MG;Simoes, JA;Montemor, EBL
在135名育龄妇女中进行了一项研究，以评价宫颈和阴道样本中进行的巴氏涂片在诊断细菌性阴道病（BV）中的作用，以验证该诊断方法并评价所用标准的重现性。使用巴氏染色法对宫颈和阴道涂片进行染色，并由两名独立的观察员进行评价。发现20%或更多线索细胞被认为是BV存在的阳性。该诊断标准在宫颈和阴道样本中的敏感性为87%，特异性为94%，阳性预测值为81%，阴性预测值为96%。两个观察者之间（kappa，0.87）以及宫颈和阴道样本之间（kappa，0.92）的BV诊断具有极好的一致性。因此，巴氏涂片中20%或更多线索细胞的存在是BV诊断的所有准确和可重复的标准，并且可以用于这种感染的疾病筛查，消除了进一步阴道样品收集的需要。
A study was carried out in 135 women of reproductive age to evaluate the role of the Papanicolaou smear performed in cervical and vaginal samples for the diagnosis of bacterial vaginosis (BV), to validate the method for this diagnosis and to evaluate the reproducibility of the criterion used. The cervical and vaginal smears were stained using the Papanicolaou method and evaluated by two separate observers. The finding of 20% or more clue cells was considered positive for the presence of BV. This diagnostic criterion presented a sensitivity of 87%, specificity of 94%, a positive predictive value of 81 %, and a negative predictive value of 96%, both in cervical and vaginal samples. There vvas excellent agreement in the diagnosis of BV between the two observers (kappa, 0.87) and between cervical and vaginal samples (kappa, 0.92). Therefore, the presence of 20% or more clue cells in the Papanicolaou smear is all accurate and reproducible criterion for the diagnosis of BV and may be used ill screening for this infection, eliminating the need for further vaginal sample collection.