Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index
Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index
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DOI：
10.1007/s00394-008-0700-4
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发表时间：
2008-03-01
影响因子：
5
通讯作者：
Jorde, Rolf
中科院分区：
文献类型：
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作者：
Konradsen, Steinar;Ag, Harald;Jorde, Rolf
基于体外研究，人们假设1,25-二羟基维生素D（1,25-维生素D）可能会促进人类体重增加，但之前的研究已经证明了关于血清1,25-维生素D与体重指数（BMI）之间关系的矛盾结果。目的探讨血清1,25-维生素D与BMI的关系。方法从某代谢与医疗生活方式管理诊所招募2887名受试者，进行横断面研究。测量BMI、25-羟基维生素D （25- oh - vd）和1,25- vd。根据BMI分为5组（< 25、25-29.9、30-34.9、35-39.9和> 39.9 kg/m）。采用多元线性回归模型进行统计分析。使用年龄和性别作为解释协变量。结果BMI升高组血清25-OH-vit D和1,25-vit D均显著降低（P < 0.001）。BMI低于39.9 kg/m(2)的患者血清25- oh -vit D水平比BMI < 25 kg/m的患者低24%，1,25-vit D水平低18%(2)。BMI与血清25-OH-vit D和1,25-vit D水平呈负相关，这使得高水平的循环1,25-vit D极不可能导致肥胖的发生。
Background Based on in vitro studies, it has been hypothesized that 1,25-dihydroxy vitamin D (1,25-vit D) may promote weight gain in humans, but previous studies have demonstrated conflicting results regarding the association between serum 1,25-vit D and body mass index (BMI). Aim of the study To evaluate the relation between serum 1,25-vit D and BMI. Methods Two thousand one hundred and eighty-seven subjects, recruited from a metabolic and medical lifestyle management clinic, were included in a cross-sectional study. BMI, 25-hydroxy vitamin D (25-OH-vit D) and 1,25-vit D were measured. The cohort was divided according to BMI in five groups (< 25, 25-29.9, 30-34.9, 35-39.9 and > 39.9 kg/m(2)). Statistical analyses were performed with multiple linear regression models. Age and gender were used as explanatory covariates. Results With increasing BMI group, there was a significant decrease in both serum 25-OH-vit D and 1,25-vit D (P < 0.001). Those with BMI > 39.9 kg/m(2) had 24% lower serum 25-OH-vit D levels and 18 % lower 1,25-vit D levels than those with BMI < 25 kg/m(2). Conclusions There is an inverse association between BMI and the serum levels of 25-OH-vit D and 1,25-vit D. This makes it highly unlikely that high levels of circulating 1,25-vit D contribute to the development of obesity.