Re-emergence of echovirus type 13 infections in 2002 in Yamagata, Japan
Re-emergence of echovirus type 13 infections in 2002 in Yamagata, Japan
复制标题
DOI：
10.1016/s0163-4453(03)00081-1
复制
发表时间：
2003-10-01
影响因子：
28.2
通讯作者：
Murayama, S
中科院分区：
文献类型：
--
作者：
Mizuta, K;Abiko, C;Murayama, S
目的：分析日本山形市Echo13型病毒（Echo13）的流行情况。方法：1999年1月至2002年12月，采用6种细胞系对6514例临床标本进行病毒分离。我们还利用2001年收集的234份血清样本对Echo13进行了血清流行病学研究。结果：2002年共分离到日本1981 ~ 2001年未检出的Echo13株50株。50岁及以上人群抗体阳性率（57.2-62.0%）高于50岁以下人群（0-14.4%）。结论：血清学研究表明，在1960年前后，抗体阳性的人在童年时期暴露于Echo13，在山形市已经存在Echo13。此外，病毒分离结果表明，在中断几十年后，Echo13在2002年左右重新出现。(C) 2003年英国传染病学会。Elsevier Ltd.出版。版权所有。
Objectives: To analyze the prevalence of echovirus type 13 (Echo13) in Yamagata, Japan.Methods: Virus isolation was performed from 6514 clinical specimens using six cell lines between January 1999 and December 2002. We also carried out a seroepidemiological study against Echo13, using 234 serum samples collected in 2001.Results: In 2002, we isolated a total of 50 Echo13 strains, which had not been detected from 1981 until 2001 in Japan. The antibody positive rate was higher (57.2-62.0%) in subjects 50 years or over than in those under 50 years (0-14.4%).Conclusions: Serological study suggested that Echo13 had been present in Yamagata until around 1960, at which time the antibody positive persons were exposed to Echo13 in their childhood. Furthermore, results of virus isolation demonstrated that Echo13 re-emerged in around 2002 after a hiatus of several decades. (C) 2003 The British Infection Society. Published by Elsevier Ltd. All rights reserved.