Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration.
Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration.
复制标题
DOI：
10.1186/s13058-014-0432-8
复制
发表时间：
2014-09-06
期刊：
影响因子：
--
通讯作者：
Nielsen TO
中科院分区：
文献类型：
--
作者：
Liu S;Foulkes WD;Leung S;Gao D;Lau S;Kos Z;Nielsen TO
据报道，FOXP 3+调节性T细胞浸润到浸润性肿瘤中与多种癌症的存活相关。然而，FOXP 3+肿瘤浸润淋巴细胞（TILs）在乳腺癌中的预后意义仍然存在争议。FOXP 3 + TILs通过组织微阵列上的免疫组织化学进行评估，该组织微阵列构建自与详细的人口统计学、生物标志物、治疗和结果数据相关的3，992名乳腺癌患者的明确队列。使用Kaplan-Meier函数和考克斯比例风险回归模型进行生存分析，以评价FOXP 3 + TIL与乳腺癌特异性生存期的相关性，根据内在亚型和细胞毒性T细胞浸润状态（如CD 8免疫组织化学定义）分层。大量FOXP 3 + TIL的存在与年轻、高级别、雌激素受体（ER）阴性、同时发生的CD 8+细胞毒性T细胞浸润、人表皮生长因子受体-2阳性（HER 2+）/ER+和核心基底亚型显著相关。在多变量生存分析中，高水平的FOXP 3 + TILs与缺乏CD 8 + T细胞浸润的ER+乳腺癌的不良生存率显著相关（风险比（HR）= 1.30，95%置信区间（CI）= 1.02至1.66）。然而，在ER+乳腺癌中，FOXP 3 + TIL与HER 2 +/ER+亚组中生存期的改善密切相关，特别是在那些同时存在CD 8 + T细胞浸润的患者中（HR = 0.48，95% CI = 0.23至0.98），对于这些患者，高水平FOXP 3 + TIL的存在与标准临床预后因素无关。FOXP 3+调节性TIL是ER+乳腺癌的不良预后指标，但在HER 2 +/ER+亚型中是有利的预后因素。FOXP 3 + TILs在乳腺癌中的预后价值取决于ER和HER 2表达状态和CD 8 + T细胞浸润。本文的在线版本（doi：10.1186/s13058-014-0432-8）包含补充材料，可供授权用户使用。
The infiltration of FOXP3+ regulatory T cells into invasive tumors has been reported to be associated with survival in a variety of cancers. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in breast cancer, however, remains controversial. FOXP3+ TILs were assessed by immunohistochemistry on tissue microarrays constructed from a well-defined cohort of 3,992 breast cancer patients linked to detailed demographic, biomarker, treatment and outcome data. Survival analyses were performed using the Kaplan-Meier function and Cox proportional hazards regression models to evaluate the association of FOXP3+ TILs with breast cancer-specific survival, stratified by intrinsic subtype and cytotoxic T-cell infiltration status (as defined by CD8 immunohistochemistry). The presence of high numbers of FOXP3+ TILs was significantly associated with young age, high grade, estrogen receptor (ER) negativity, concurrent CD8+ cytotoxic T-cell infiltration, and human epidermal growth factor receptor-2 positive (HER2+)/ER+ and core basal subtypes. On multivariate survival analysis, a high level of FOXP3+ TILs was significantly associated with poor survival in ER+ breast cancers that lacked CD8+ T-cell infiltrates (hazard ratio (HR) = 1.30, 95% confidence interval (CI) = 1.02 to 1.66). However, in ER+ breast cancers, FOXP3+ TILs were strongly associated with improved survival in the HER2+/ER+ subgroup, particularly in those with co-existent CD8+ T-cell infiltrates (HR = 0.48, 95% CI = 0.23 to 0.98), for which the presence of high levels of FOXP3+ TILs was independent of standard clinical prognostic factors. FOXP3+ regulatory TILs are a poor prognostic indicator in ER+ breast cancer, but a favorable prognostic factor in the HER2+/ER+ subtype. The prognostic value of FOXP3+ TILs in breast cancer differs depending on ER and HER2 expression status and CD8+ T-cell infiltration. The online version of this article (doi:10.1186/s13058-014-0432-8) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
45.3
作者：
Joensuu, Heikki;Bono, Petri;Kellokumpu-Lehtinen, Pirkko-Liisa
通讯作者：
Kellokumpu-Lehtinen, Pirkko-Liisa
影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
影响因子：
11.2
作者：
Gobert, Michael;Treilleux, Isabelle;Menetrier-Caux, Christine
通讯作者：
Menetrier-Caux, Christine
影响因子：
4.2
作者：
Aruga, Tomoyuki;Suzuki, Eiji;Kuroi, Katsumasa
通讯作者：
Kuroi, Katsumasa
影响因子：
4.5
作者：
Li, Jin F.;Chu, Yi W.;Xu, Ming
通讯作者：
Xu, Ming