Categorizing diffuse parenchymal lung disease in children
Categorizing diffuse parenchymal lung disease in children
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DOI：
10.1186/s13023-015-0339-1
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发表时间：
2015-09-25
影响因子：
3.7
通讯作者：
Kroener, Carolin
中科院分区：
文献类型：
--
作者：
Griese, Matthias;Irnstetter, Armin;Kroener, Carolin
背景资料：本研究的目的是验证一个系统的和实用的分类系统，允许动态分类的儿科DPLD，无论患者data.Methods的完整性：这项研究是基于2322名儿童提交到1997年和2012年之间的kids肺登记。在这些儿童中，791人被分配到12个DPLD类别，超过2/3属于主要在婴儿期出现的类别。儿科DPLD分类系统的工作流程包括（i）生成最终工作诊断，决定是否存在（ii）DPLD和（iii）全身或仅肺部疾病，以及（iv）分配至类别和子类别。使用100 cases.Results的系统样本重新测试了这个工作流程的有效性和观察者之间的依赖性：两个盲评分员分配超过80%的重新分类的情况下相同。不相同的分配是由于缺乏升值的所有可用的细节，知识不足的分类规则的评分员，不完整的患者数据，和缺陷的分类系统本身.Conclusions：这项研究提供了一个合适的工作流程和动手规则的儿科DPLD的分类。查明了潜在的缺陷，为制定基于共识的国际分类准则奠定了基础。
Background: Aim of this study was to verify a systematic and practical categorization system that allows dynamic classification of pediatric DPLD irrespective of completeness of patient data.Methods: The study was based on 2322 children submitted to the kids-lung-register between 1997 and 2012. Of these children 791 were assigned to 12 DPLD categories, more than 2/3 belonged to categories manifesting primarily in infancy. The work-flow of the pediatric DPLD categorization system included (i) the generation of a final working diagnosis, decision on the presence or absence of (ii) DPLD and (iii) a systemic or lung only condition, and (iv) the allocation to a category and subcategory. The validity and inter-observer dependency of this workflow was re-tested using a systematic sample of 100 cases.Results: Two blinded raters allocated more than 80 % of the re-categorized cases identically. Non-identical allocation was due to lack of appreciation of all available details, insufficient knowledge of the classification rules by the raters, incomplete patient data, and shortcomings of the classification system itself.Conclusions: This study provides a suitable workflow and hand-on rules for the categorization of pediatric DPLD. Potential pitfalls were identified and a foundation was laid for the development of consensus-based, international categorization guidelines.