Molecular mechanisms of nucleolar DNA damage checkpoint response.
Molecular mechanisms of nucleolar DNA damage checkpoint response.
复制标题
核仁 DNA 损伤检查点反应的分子机制。
DOI：
10.1016/j.tcb.2023.02.003
复制
发表时间：
2023
影响因子：
19
通讯作者：
Yan,Shan
中科院分区：
文献类型：
--
作者：
Li,Jia;Yan,Shan
核糖体DNA （rDNA）在核核中转录成RNA，经常受到不同应激条件的挑战。然而，核仁DNA损伤反应（DDR）途径的潜在机制尚不清楚。在这里，我们对核核DDR检查点途径如何被不同的应力或液-液相分离（LLPS）激活提供了不同的观点。
Ribosomal DNA (rDNA) is transcribed into RNA in the nucleolus and is often challenged by different stress conditions. However, the underlying mechanisms of nucleolar DNA damage response (DDR) pathways remain elusive. Here, we provide distinct perspectives on how nucleolar DDR checkpoint pathways are activated by different stresses or by liquid–liquid phase separation (LLPS).