The comparative effects of intravenous nicardipine and prostaglandin E1 on the cerebral pial arteriolar constriction seen after unclamping of an aortic cross-clamp in rabbits
The comparative effects of intravenous nicardipine and prostaglandin E1 on the cerebral pial arteriolar constriction seen after unclamping of an aortic cross-clamp in rabbits
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DOI：
10.1213/01.ane.0000253493.76249.54
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发表时间：
2007-03-01
影响因子：
5.7
通讯作者：
Dohi, Shuji
中科院分区：
文献类型：
--
作者：
Kumazawa, Masahiko;Iida, Hiroki;Dohi, Shuji
背景技术背景：有效的血管扩张剂尼卡地平和前列腺素E1（PGE 1）可用于治疗主动脉手术期间的全身性高血压或肺动脉高压。静脉输注前（基线）和静脉输注开始后15分钟（预夹）（0.9%生理盐水[对照组]，尼卡地平[0.1，1.0或10 μ g（.）kg（-1）（.）min（-1）]或PGE 1 [0.1或1.0 μ g（.）kg（-1）（.）结果：对照组在主动脉阻断后60 min内，动脉直径明显减小（最大值在60 min，大动脉直径减小16%，小动脉直径减小27%，小动脉直径减小< 75 μ m）。尽管在最小剂量的尼卡地平下，主动脉开放诱导的血管收缩不受影响，但在较大剂量下，大和小动脉中的血管收缩均显著减弱（60 min时，大动脉的残余血管收缩为-10%和-6%，小动脉为-18%和-10%）。软脑膜小动脉收缩观察到在5分钟或以上后，在对照组松开没有改变PGE 1在无论是大或小arterioles.CONCLUSIONS：较大剂量的尼卡地平，但无论是剂量的PGE 1，衰减主动脉松开引起的持续脑软脑膜小动脉收缩。
BACKGROUND: The potent vasodilators nicardipine and prostaglandin E1 (PGE1) are useful for the treatment of systemic hypertension or pulmonary hypertension during aortic surgery.METHODS: We measured cerebral pial arteriolar diameters, using a rabbit closed cranial window preparation: before (baseline) and 15 min after the start of an IV infusion (preclamp) (0.9% saline [control group], nicardipine [at 0.1, 1.0, or 10 mu g (.) kg(-1) (.) min(-1)], or PGE1 [at 0.1 or 1.0 mu g (.) kg(-1) (.) min(-1)]), just after aortic clamping, 20 min after clamping, and at 0-60 min after unclamping.RESULTS: In the control group, a significant decrease in diameter persisted for at least 60 min after unclamping (maximum [at 60 min], -16% for large [>= 75 mu m], and -27% for small [< 75 mu m] arterioles versus baseline). Although the aortic unclamping-induced vasoconstriction was unaffected under the smallest dose of nicardipine, it was significantly attenuated under larger doses in both large and small arterioles (residual vasoconstriction, -10% and -6% for large and -18% and -10% for small arterioles; at 60 min). The pial arteriolar constriction observed at 5 min or more after unclamping in the control group was not altered by PGE1 in either large or small arterioles.CONCLUSIONS: The larger doses of nicardipine, but neither dose of PGE1, attenuated aortic unclamping-induced sustained cerebral pial arteriolar constriction.