Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis.
Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis.
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DOI：
10.2147/tcrm.s131945
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发表时间：
2017
影响因子：
2.8
通讯作者：
Amraei M
中科院分区：
文献类型：
--
作者：
Moayeri A;Mohamadpour M;Mousavi SF;Shirzadpour E;Mohamadpour S;Amraei M
2 型糖尿病 (T2DM) 患者骨折的风险增加。据报道，骨折风险的增加取决于骨骼部位、糖尿病持续时间、研究设计、胰岛素使用等。本荟萃分析旨在调查 T2DM 与骨折风险和可能的危险因素之间的关联。截至 2016 年 5 月，检索了包括 PubMed、Institute for Scientific Information 和 Scopus 在内的不同数据库。所有关于 T2DM 与骨折风险之间关联的流行病学研究均被纳入。从这些论文中获得的相关数据通过随机效应模型进行分析，并通过漏斗图评估发表偏倚。所有分析均由 R 软件（版本 3.2.1）和 STATA（版本 11.1）完成。选择了 30 份符合条件的研究进行荟萃分析。我们发现 T2DM 与髋部、椎骨或足部骨折之间存在统计学上显着的正相关性，而 T2DM 与腕部、肱骨近端或踝部骨折之间没有相关性。总体而言，T2DM 与任何骨折的风险增加相关（总体相对风险=1.05，95% 置信区间：1.04、1.06），并且随着年龄、糖尿病病程和胰岛素治疗的增加而增加。我们的研究结果强烈支持 T2DM 与整体骨折风险增加之间的关联。这些发现强调了糖尿病患者采取骨折预防策略的必要性。
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fractures. A variable increase in fracture risk has been reported depending on skeletal site, diabetes duration, study design, insulin use, and so on. The present meta-analysis aimed to investigate the association between T2DM with fracture risk and possible risk factors. Different databases including PubMed, Institute for Scientific Information, and Scopus were searched up to May 2016. All epidemiologic studies on the association between T2DM and fracture risk were included. The relevant data obtained from these papers were analyzed by a random effects model and publication bias was assessed by funnel plot. All analyses were done by R software (version 3.2.1) and STATA (version 11.1). Thirty eligible studies were selected for the meta-analysis. We found a statistically significant positive association between T2DM and hip, vertebral, or foot fractures and no association between T2DM and wrist, proximal humerus, or ankle fractures. Overall, T2DM was associated with an increased risk of any fracture (summary relative risk =1.05, 95% confidence interval: 1.04, 1.06) and increased with age, duration of diabetes, and insulin therapy. Our findings strongly support an association between T2DM and increased risk of overall fracture. These findings emphasize the need for fracture prevention strategies in patients with diabetes.