Risk factors of atopic dermatitis in Korean schoolchildren: 2010 international study of asthma and allergies in childhood
Risk factors of atopic dermatitis in Korean schoolchildren: 2010 international study of asthma and allergies in childhood
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DOI：
10.12932/ap0621.34.1.2016
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发表时间：
2016-03-01
影响因子：
5
通讯作者：
Ahn, Kangmo
中科院分区：
文献类型：
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作者：
Park, Yong Mean;Lee, So-Yeon;Ahn, Kangmo
背景与目的：我们旨在分析2010年韩国学龄儿童特应性皮炎（AD）的危险因素。方法：对随机选择的6-7岁儿童和12-13岁青少年进行全国性横断面研究。通过韩国版儿童哮喘和过敏调查问卷（ISAAC）获取信息，并进行皮肤点刺测试。采用逻辑回归方法选择诊断为 AD 的儿童进行危险因素分析。结果：我们纳入了 4,003 名 6-7 岁儿童（M/F=2,021/1,982）和 4,112 名 12-13 岁儿童（M/F=2,029/2,083）。在 6-7 岁儿童中，AD 诊断的终生患病率为 35.6% (N=1,424)。另一方面，在 12 至 13 岁年龄组中，AD 诊断的终生患病率为 24.2% (N=981)。对67岁儿童进行单因素logistic回归分析，可能的危险因素包括特应性、父母有过敏性疾病史、婴儿期使用抗生素、婴儿期搬入新建房屋史、房屋内有明显霉菌、12个月内重新装修过房屋等。调整后统计显着性仍然存在。然而，婴儿期抗生素使用和 12 个月内重塑作为 AD 危险因素并无统计学意义。相比之下，青少年的多变量逻辑回归分析表明，女性、特应性、父母过敏性疾病史、房屋中存在可见霉菌以及婴儿期搬入新建房屋的历史与 AD 相关。 AD 与其他危险因素之间没有显着关联。结论：在韩国学童中，特应性、父母在场等危险因素。过敏性疾病、婴儿期搬入新建房屋以及房屋内可见霉菌均与 AD 相关。
Background & Objective: We aimed to analyse the risk factors of atopic dermatitis (AD) in Korean schoolchildren in 2010.Methods: A nationwide, cross-sectional study was conducted in children aged 6-7 years and adolescents aged 12-13 years who were randomly selected. Information was obtained through a Korean version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC), and skin prick tests were performed. AD-diagnosed children were selected for risk factor analysis by using logistic regression.Results: We enrolled 4,003 children (M/F=2,021/1,982) in aged 6-7 years and 4,112 children (M/F=2,029/2,083) in 12-13 years. In children aged 6-7 years, the lifetime prevalence of AD diagnosis was 35.6% (N=1,424). On the other hand, in the 12 to 13 year age group, the lifetime prevalence of AD diagnosis was 24.2% (N=981). In the univariate logistic regression analysis in 67 year-old children, possible risk factors were atopy, a parental history of allergic disease, the use of antibiotics during infancy, a history of having moved into a newly built house during infancy, the presence of visible mould in the house, and remodelling of house within 12 months. The statistical significance persisted after adjustment. However, antibiotic use during infancy and remodelling within 12 months showed no statistical significance as a risk factor for AD. In contrast, multivariate logistic regression analysis in adolescents demonstrated that female sex, atopy, a parental history of allergic diseases, the presence of visible mould in the house, and a history of having moved into a newly built house during infancy was associated with AD. There was no significant association between AD and other risk factors.Conclusion: In Korean schoolchildren, risk factors such as atopy, the presence of parental. allergic diseases, moving into a newly built house during infancy and visible mould in the house were associated with AD.