The emerging role of Twist proteins in hematopoietic cells and hematological malignancies.
The emerging role of Twist proteins in hematopoietic cells and hematological malignancies.
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DOI：
10.1038/bcj.2014.22
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发表时间：
2014-04-25
影响因子：
12.8
通讯作者：
Bonnefoy, N.
中科院分区：
文献类型：
--
作者：
Merindol, N.;Riquet, A.;Szablewski, V.;Eliaou, J-F;Puisieux, A.;Bonnefoy, N.
Twist 1和Twist 2（Twist 1 -2）是基本螺旋-环-螺旋家族的两个转录因子，已被确定为间充质细胞谱系的胚胎发生和发育程序的主转录调节因子。它们在上皮源性癌症中的肿瘤发生和上皮向间质转化中的作用也已被彻底表征。最近，新出现的证据也表明Twist 1 -2在造血细胞的功能和发育以及许多血液恶性肿瘤的生存和发展中起关键作用。本文综述了Twist 1 -2在单核细胞、T细胞和B淋巴细胞活化以及相关血液恶性肿瘤中的作用。
Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages. Their role in oncogenesis in epithelium-derived cancer and in epithelial-to-mesenchymal transition has also been thoroughly characterized. Recently, emerging evidence also suggests a key role for Twist1–2 in the function and development of hematopoietic cells, as well as in survival and development of numerous hematological malignancies. In this review, we summarize the latest data that depict the role of Twist1–2 in monocytes, T cells and B lymphocyte activation, and in associated hematological malignancies.
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影响因子：
20.3
作者：
Cameron, EE;Baylin, SB;Herman, JG
通讯作者：
Herman, JG
影响因子：
82.9
作者：
Chiarle, R;Simmons, WJ;Inghirami, G
通讯作者：
Inghirami, G
影响因子：
7.8
作者：
Degerman, Sofie;Siwicki, Jan Konrad;Roos, Goran
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Roos, Goran
影响因子：
50.3
作者：
Ansieau, Stephane;Bastid, Jeremy;Puisieux, Alain
通讯作者：
Puisieux, Alain
影响因子：
64.5
作者：
BENEZRA, R;DAVIS, RL;WEINTRAUB, H
通讯作者：
WEINTRAUB, H