Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program
Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program
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DOI：
10.1093/jnci/dju316
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发表时间：
2014-11-01
影响因子：
10.3
通讯作者：
Conant, Emily F.
中科院分区：
文献类型：
--
作者：
McCarthy, Anne Marie;Kontos, Despina;Conant, Emily F.
Background Early data on breast cancer screening utilizing digital breast tomosynthesis (DBT) combined with digital mammography (DM) have shown improvements in false-positive and false-negative screening rates compared with DM alone. However, these trials were performed at sites where conventional mammographic screening was concurrently performed, possibly leading to selection biases or with complex, multireader algorithms not reflecting general clinical practice. Our study reports the impact on screening outcomes for DBT screening implemented in an entire clinic population.Methods Recall rates, cancer detection, and positive predictive values of screening were compared for 15 571 women screened with DBT and 10 728 screened with DM alone prior to DBT implementation at a single breast imaging center. Generalized linear mixed-effects models were used to estimate the odds ratio (OR) for recall rate adjusted for age, race, presence of prior mammograms, breast density and reader. All statistical tests were two-sided.Results DBT screening showed a statistically significant reduction in recalls compared to DM alone. For the entire population, there were 16 fewer recalls (8.8% vs 10.4%, P
