Fungal Infections in Hematopoietic Stem Cell Transplantation and Solid-Organ Transplantation-Focus on Aspergillosis
Fungal Infections in Hematopoietic Stem Cell Transplantation and Solid-Organ Transplantation-Focus on Aspergillosis
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DOI：
10.1016/j.ccm.2009.03.001
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发表时间：
2009-06-01
影响因子：
5.7
通讯作者：
Anaissie, Elias
中科院分区：
文献类型：
--
作者：
Nucci, Marcio;Anaissie, Elias
侵袭性真菌感染（IFIs）是造血干细胞移植和实体器官移植受者的主要并发症。过去 20 年来，移植受者中 IFI 的发病率有所增加，并且这些感染仍然与高发病率和死亡率相关。本文回顾了指导移植受者 IFI 管理的重要概念，包括流行病学趋势、新的危险因素以及感染、病原体、治疗和预防这些感染的时间表。重点关注侵袭性曲霉菌病。
Invasive fungal infections (IFIs) represent a major complication in recipients of hematopoietic stem cell transplantation and solid-organ transplantation. The incidence of IFIs in transplant recipients has increased over the past 20 years, and these infections continue to be associated with high morbidity and mortality. This article reviews the important concepts guiding the management of IFIs in transplant recipients, including epidemiologic trends, new risk factors, and a timetable of infections, pathogens, therapy, and prevention of these infections. An emphasis is given to invasive aspergillosis.