Determinants of Salivary Cotinine among Smokeless Tobacco Users: A Cross-Sectional Survey in Bangladesh.
Determinants of Salivary Cotinine among Smokeless Tobacco Users: A Cross-Sectional Survey in Bangladesh.
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DOI：
10.1371/journal.pone.0160211
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Siddiqi K
中科院分区：
文献类型：
--
作者：
Huque R;Shah S;Mushtaq N;Siddiqi K
世界上80%以上的无烟烟草(ST)产品在南亚消费，但人们对其消费行为、成瘾性和有毒特性知之甚少。这篇论文首次描述了孟加拉国吸烟者唾液可替宁浓度与其社会人口学特征和烟草使用行为之间的关系。在孟加拉国达卡的一项对ST使用者的调查中，我们有目的地招募了200名不吸烟但经常食用ST的成年人。进行了面对面的访谈，以获得有关社会人口学和ST使用行为的信息，并收集了唾液样本以测量可替宁浓度。简单和多元线性回归分析被用来检验转化成对数的唾液可替宁浓度和其他研究变量之间的关联。ST使用者的可替宁几何平均值为380 ng/ml(GSD：2)。每天使用ST的总持续时间与可替宁浓度有统计学意义的相关性。在多变量模型中，其他ST使用特征，包括ST使用的类型和数量、吞咽烟草汁、冲动和冲动的强度以及试图减少烟草使用与可替宁浓度没有发现关联。这是孟加拉国第一份研究可替宁在ST使用者中的浓度的报告，它指出了高水平的成瘾。这需要有效的烟草控制政策，以帮助ST戒烟和预防。
More than 80% of all smokeless tobacco (ST) products in the world are consumed in South Asia; yet little is known about their consumption behaviour, addictiveness, and toxic properties. This paper, for the first time, describes associations between salivary cotinine concentrations among ST users in Bangladesh and their socio-demographic characteristics and tobacco use behaviours. In a survey of ST users in Dhaka, Bangladesh, we purposively recruited 200 adults who were non-smokers but consumed ST on a regular basis. In-person interviews were conducted to obtain information about socio-demographic and ST use behaviours, and saliva samples were collected to measure cotinine concentration. Simple and multiple linear regression analyses were conducted to test associations between the log transformed salivary cotinine concentration and other study variables. The geometric mean of cotinine concentration among ST users was 380ng/ml (GSD:2). Total duration of daily ST use in months had a statistically significant association with cotinine concentration. Other ST use characteristics including type and quantity of ST use, swallowing of tobacco juice, urges and strength of urges and attempts to cut down on tobacco use were not found to be associated with cotinine concentration in a multivariable model. This is the first report from Bangladesh studying cotinine concentration among ST users and it points towards high levels of addiction. This warrants effective tobacco control policies to help ST cessation and prevention.