A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye
A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye
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DOI：
10.1016/j.actbio.2013.11.004
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发表时间：
2014-02-01
影响因子：
9.7
通讯作者：
Abe, Toshiaki
中科院分区：
文献类型：
--
作者：
Nagai, Nobuhiro;Kaji, Hirokazu;Abe, Toshiaki
设计能够将多种药物递送至眼后段的药物递送系统是视网膜疾病治疗中具有挑战性的任务。我们报告了一种聚合物装置，用于以独立控制的释放速率进行多药物经巩膜递送。该装置包括一个微型水库，控释盖和三种不同的荧光制剂，这是由光聚合三（乙二醇）二甲基丙烯酸酯（TEGDM）和聚（乙二醇）二甲基丙烯酸酯（PEGDM）。每种荧光剂的释放速率通过改变其制剂和覆盖物中的PEGDM/TEGDM比率来控制。释放动力学似乎与PEGDM/TEGDM聚合物的溶胀比有关。当将该装置植入到大鼠巩膜上时，在植入4周期间在眼组织中可观察到荧光，并在植入部位周围局部分布。我们的聚合物系统，它可以管理多种化合物具有不同的动力学，提供了长期的行动和侵入性较小的经巩膜给药，并预计将提供新的工具，用于治疗后眼部疾病的新的治疗方式。(C)2013 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover and three different fluorescent formulations, which were made of photopolymeized tri(ethyleneglycol)dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each fluorescent is controlled by varying the PEGDM/TEGDM ratio in its formulation and the cover. The release kinetics appeared to be related to the swelling ratio of the PEGDM/TEGDM polymers. When the devices were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks' implantation and distributed locally around the implantation site. Our polymeric system, which can administer multiple compounds with distinct kinetics, provides prolonged action and less invasive transscleral administration, and is expected to provide new tools for the treatment of posterior eye diseases with new therapeutic modalities. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.