Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense
Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense
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DOI：
10.1126/science.1076064
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发表时间：
2002-11-29
期刊：
影响因子：
56.9
通讯作者：
Nikolich-Zugich, J
中科院分区：
文献类型：
--
作者：
Messaoudi, I;Guevara-Patiño, JA;Nikolich-Zugich, J
主要组织相容性复合体(MHC)编码的分子通过向T细胞递呈抗原肽来调控免疫反应。编码这些分子的基因的广泛多态性被认为通过扩大可用于T细胞识别的抗原肽的阵列来增强免疫防御，但支持这一机制在对抗病原体方面的重要性的直接证据有限。在这里，我们将MHC多态驱动的细胞毒性T淋巴细胞(CTL)谱系的多样化与高亲和力、保护性抗病毒T细胞的产生和卓越的抗病毒防御联系起来。因此，MHC多态在免疫防御中的许多有益作用可能是由于它对选定的CTL谱系的性质产生了关键影响。
Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.