Hot flashes and awakenings among midlife women.
Hot flashes and awakenings among midlife women.
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中年女性的潮热和觉醒。
DOI：
10.1093/sleep/zsz131
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发表时间：
2019
期刊：
影响因子：
5.6
通讯作者：
Matthews,KarenA
中科院分区：
文献类型：
--
作者：
Thurston,RebeccaC;Chang,Yuefang;Buysse,DanielJ;Hall,MarticaH;Matthews,KarenA
研究目的对于大多数女性来说，更年期都会伴随着潮热和睡眠问题。尽管据报道潮热会使女性从睡眠中醒来，但在少数使用睡眠和潮热客观测量的研究中，潮热和夜间觉醒之间的联系并不一致。在一组特征明确的中年女性中，我们研究了客观评估的潮热与活动记录定义的睡眠唤醒之间的关联。我们假设，相对于没有潮热的几分钟，在客观潮热期间觉醒发作的可能性更大。 方法 围绝经期和绝经后中年女性在家中进行 24 小时的潮热（胸骨皮肤电导）和睡眠（体动记录仪）同步客观测量。使用广义估计方程比较潮热期间的几分钟内醒来的可能性与潮热前几分钟的可能性。结果我们研究了 168 名至少有一项客观夜间潮热和体动记录数据的女性。体动记录仪评估的觉醒发作与 78% 的客观潮热同时发生。我们发现，相对于之前的几分钟（–10 至 –1 分钟），在客观潮热期间的几分钟内（0 至 +5 分钟：OR [95% CI] = 5.31（4.46 至 6.33）；p< .0001）醒来的可能性增加。无论女性是否报告客观潮热，醒来的可能性都会增加。结论在这些接受睡眠和潮热客观测量的女性中，观察到大多数潮热都伴有夜间觉醒。
Study ObjectivesFor most women, the menopause is accompanied by hot flashes and sleep problems. Although hot flashes reportedly wake women from sleep, in the few studies that have used objective measures of both sleep and hot flashes, links between hot flashes and nocturnal awakening have been inconsistent. In a well-characterized cohort of midlife women, we examined the association between objectively assessed hot flashes and actigraphically defined wake from sleep. We hypothesized that wake episodes would be more likely during an objective hot flash relative to minutes without a hot flash.MethodsPeri- and postmenopausal midlife women underwent simultaneous objective measurement of hot flashes (sternal skin conductance) and sleep (actigraphy) over 24 hours in the home. The likelihood of waking in the minutes during the hot flash relative to the minutes preceding the hot flash was compared using generalized estimating equations.ResultsWe studied 168 women with at least one objective nocturnal hot flash and actigraphy data. Actigraphy-assessed wake episodes were concurrent with 78% of the objective hot flashes. We found an increased likelihood of wake in the minutes during the objective hot flash (0 to +5 min: OR [95% CI] = 5.31 (4.46 to 6.33);p< .0001) relative to the minutes preceding it (–10 to –1 min). The increased likelihood of wake occurred irrespective of whether the women reported the objective hot flash.ConclusionAmong these women who underwent objective measurement of sleep and hot flashes, nocturnal wakefulness was observed with the majority of hot flashes.