A novel method for activity monitoring in small non-human primates
A novel method for activity monitoring in small non-human primates
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DOI：
10.1258/0023677053739783
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发表时间：
2005-04-01
影响因子：
2.4
通讯作者：
Scott, EAM
中科院分区：
文献类型：
--
作者：
Mann, TM;Williams, KE;Scott, EAM
自发活动的模式是动物和人类幸福的宝贵反映，正因为如此，调查经常将某种形式的活动监测纳入他们的研究。人们普遍认为，活动监测以及一般行为评估应包括在初始CNS安全性药理学筛选中。随着将活动测定作为重点或辅助手段的绒猴研究数量的增加，我们希望评估常用方法的替代方法。该方法基于目前用于人类活动监测的小型化加速度计技术。使用Actiwatch（R）-Minis连续14天监测两组不同圈养的绒猴的活动。A组由4对混合性别动物组成，B组由8只分组饲养的雄性动物组成。生成了工作日和周末期间的活动概况。这些设备捕获了可量化的数据，这些数据显示了两个不同居住群体之间的总活动差异，并揭示了工作日和周末之间活动时间分布的组内变化。Actiwatch（R）-Mini已被证明可以通过非侵入性监测的方式，在单个竞技场中记录多只动物的回顾性数据记录活动计数。
Patterns of spontaneous activity are valuable reflections of well-being in animals and humans and, because of this, investigations have frequently incorporated some form of activity monitoring into their studies. It is widely believed that activity monitoring, alongside assessments of general behaviour, should be included in initial CNS safety pharmacology screening. As the number of marmoset studies having actimetry as their focus, or as an adjunct, is increasing, we wished to evaluate an alternative approach to those commonly used. The method is based on miniaturized accelerometer technologies, currently used for human activity monitoring.Actiwatch (R)-Minis were used to monitor the activity of two groups of differently housed marmosets for 14 consecutive days. Group A consisted of four mixed-sex pairs of animals and group B comprised eight group-housed males. Activity profiles were generated for weekday and weekend periods. The devices captured quantifiable data which showed differences in total activity between the two differently housed groups and revealed intragroup variations in the temporal spread of activity between weekdays and weekends. The Actiwatch (R)-Mini has been shown to generate retrospective, data-logged activity counts recorded from multiple animals in a single arena by means of non-invasive monitoring.