VEGETAL MESSENGER-RNA LOCALIZATION DIRECTED BY A 340-NT RNA SEQUENCE ELEMENT IN XENOPUS OOCYTES
VEGETAL MESSENGER-RNA LOCALIZATION DIRECTED BY A 340-NT RNA SEQUENCE ELEMENT IN XENOPUS OOCYTES
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DOI：
10.1126/science.1546297
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发表时间：
1992-02-21
期刊：
影响因子：
56.9
通讯作者：
MELTON, DA
中科院分区：
文献类型：
--
作者：
MOWRY, KL;MELTON, DA
包含在一个细胞，受精卵，是信息，最终将指定整个有机体。在早期胚胎卵裂过程中，细胞获得不同的命运，它们在发育潜力上的差异可能由卵中信息分子的定位来解释。的机制，其中Vg1 RNA，母亲的mRNA，易位到植物极的爪蟾卵母细胞可能表明如何发展的信号本地化。本文提供的数据表明，存在于Vg1 RNA的3'非翻译区的340个核苷酸的定位信号足以指导RNA定位到植物极。
Contained within a single cell, the fertilized egg, is information that will ultimately specify the entire organism. During early embryonic cleavages, cells acquire distinct fates and their differences in developmental potential might be explained by localization of informational molecules in the egg. The mechanisms by which Vg1 RNA, a maternal mRNA, is translocated to the vegetal pole of Xenopus oocytes may indicate how developmental signals are localized. Data presented here show that a 340-nucleotide localization signal present in the 3' untranslated region of Vg1 RNA is sufficient to direct RNA localization to the vegetal pole.