Asthma experience in an occupational and environmental medicine clinic. Low-dose reactive airways dysfunction syndrome.
Asthma experience in an occupational and environmental medicine clinic. Low-dose reactive airways dysfunction syndrome.
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职业和环境医学诊所的哮喘经验。
DOI：
10.1097/00043764-199410000-00017
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Hutt,D
中科院分区：
文献类型：
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作者：
Kipen,HM;Blume,R;Hutt,D
成人发病的哮喘的病因尚不完全清楚。高强度接触刺激物是一种公认的危险因素，这种情况被称为反应性气道功能障碍综合征。不太强烈和不太剧烈的刺激物接触对哮喘的影响仍有待澄清。我们报告了 10 例在暴露于明显但明显“可耐受”水平的吸入刺激物的情况下发生的非致敏性成人哮喘病例。这一系列 10 例病例占我们环境和职业医学转诊诊所 5 年来所见经证实哮喘病例的 31%。我们认为有必要进一步探索这种低剂量反应性气道功能障碍综合征的现象。
The etiology of adult-onset asthma is incompletely understood. Highintensity exposure to irritants is one accepted risk factor and such cases are termed Reactive Airways Dysfunction Syndrome. The contribution to asthma of less intense and less acute exposure to irritants remains to be clarified. We report on 10 cases of nonsensitization adult-onset asthma in settings of exposure to noticeable but distinctly "tolerable" levels of inhalation irritants This series of 10 cases represent 31% of verified asthma cases seen in our environmental and occupational medicine referral clinic over a 5-year period We believe further exploration of this phenomenon of low dose Reactive Airways Dysfunction Syndrome is warranted.