The area postrema is involved in paraquat-induced conditioned aversion behavior and neuroendocrine activation of the hypothalamic-pituitary-adrenal axis.
The area postrema is involved in paraquat-induced conditioned aversion behavior and neuroendocrine activation of the hypothalamic-pituitary-adrenal axis.
复制标题
后区参与百草枯诱导的条件性厌恶行为和下丘脑-垂体-肾上腺轴的神经内分泌激活。
DOI：
10.1016/0006-8993(95)01419-5
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发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
Edwards,GL
中科院分区：
文献类型：
--
作者：
Edmonds,BK;Edwards,GL
百草枯是一种能够引起条件性味觉厌恶（CTA）的除草剂，这是中毒的一种行为反应特征。最后区（AP）是一个后脑脑室周围器官，以前被证明在介导百草枯诱导的毒性体征（即CTA和体重减轻）方面很重要。在以AP为中心病变的Sprague-Dawley大鼠（APX）和给予百草枯（25 μmol/kg）或生理盐水（1 ml/kg）的假手术（SHM）大鼠中研究了百草枯诱导CTA的神经基质与下丘脑-垂体-肾上腺（HPA）轴激活之间的关系。注射百草枯的剂量足以条件味觉厌恶，但没有产生明显的毒性的其他迹象，显着增加血浆皮质酮浓度SHM大鼠给药后4小时。与假手术对照组相比，百草枯诱导的HPA轴激活在AP损伤大鼠中显著减弱。这些结果表明，最后区是一个共同的神经基板的行为和神经内分泌反应的百草枯。
Paraquat is a herbicide capable of eliciting conditioned taste aversion (CTA), a behavioral response characteristic of toxicosis. The area postrema (AP) is a hindbrain circumventricular organ previously shown to be important in mediating signs of paraquat-induced toxicity, namely CTA and weight loss. The relationship between neural substrates for paraquat-induced CTA and activation of the hypothalamic-pituitary-adrenal (HPA) axis was investigated in Sprague-Dawley rats with lesions centered on the AP (APX) and sham-operated (SHM) rats administered paraquat (25 μmol/kg) or saline (1 ml/kg). Injection of paraquat at a dose sufficient to condition taste aversion, but produce no other signs of overt toxicity, significantly increased plasma corticosterone concentrations in SHM rats up to 4 h after administration. Paraquat-induced activation of the HPA axis was significantly attenuated in AP-lesioned rats as compared to sham-operated controls. These findings suggest the area postrema is a common neural substrate for the behavioral and neuroendocrine responses to paraquat.