Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation.
Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation.
复制标题
蒙药通过FXR/ lxr介导的P2X7R/NLRP3/NF-κB通路激活治疗2型糖尿病合并非酒精性脂肪肝
DOI：
10.1016/j.chmed.2022.06.003
复制
发表时间：
2022-07
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
2型糖尿病（T2 DM）和非酒精性脂肪肝（NAFLD）是世界上最有问题的代谢性疾病。NAFLD包括一系列的严重程度，从单纯性脂肪变性到非酒精性脂肪性肝炎（NASH）和纤维化，增加了肝硬化和肝细胞癌的风险。重要的是，NAFLD与肥胖密切相关，并与胰岛素抵抗和T2DM密切相关。2型糖尿病和非酒精性脂肪肝（T2DM-NAFLD）在蒙医学上分别被称为锡克日西京病和通拉格消化不良病。消渴日息经病可能发展为汤加减。近年来，许多蒙药对T2DM-NAFLD有较好的治疗作用，如沙米草、哈力雅素等（骆驼胎盘干粉）、地格达-4（肋柱花全草、黄连根茎、栀子成熟果实、石竹全草）、光明眼四味汤散（石盐、诃子成熟果实、山茱萸根茎、山胡椒果串）、通拉加-5（石榴熟果、肉桂皮、砂仁熟果、山胡椒果串、红花花），（旋覆花根茎、栀子成熟果实、桔梗根茎、黄连根茎、云实心材）、利肝石榴八味散（石榴的成熟果实、肉桂的树皮、砂仁的成熟果实、胡椒的果串、红花的花、草果的成熟果实、甘草的根茎）等。蒙医治病的原则：通过平衡"三精或根本"和"七种元素"，强化肝肾功能，输送营养，增强体力和抗病能力，并结合药物进行综合调理治疗。然而，其分子机制仍不清楚。本文就蒙药通过脂质敏感性核受体（即脂敏核受体）激活P2X7 R/NLRP 3/NF-κ B炎症通路，可能成为治疗T2DM-NAFLD的一个有前景的研究方向作一前景展望。FXR和LXR）。
Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are the most problematic metabolic diseases in the world. NAFLD encompasses a spectrum of severity, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis and hepatocellular carcinoma. Importantly, NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM. T2DM and NAFLD (T2DM-NAFLD) are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively, in Mongolian medicine. Xike Rixijing Disease maybe develop into Tonglaga Indigestion Disease. Forturnately many Mongolian medicines show efficient treatment of T2DM-NAFLD, such as Agriophyllum squarrosum, Haliyasu (dried powder of camel placenta), Digeda-4 (herbs of Lomatogonium carinthiacum, rhizomata of Coptis chinensis, ripe fruits of Gardenia jasminoides, herbs of Dianthus superbus), Guangmingyan Siwei Decoction Powder (Halite, ripe fruits of Terminalia chebula, rhizomata of Zingiber officinale, fruit clusters of Piper longum), Tonglaga-5 (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piper longum, flowers of Carthamus tinctorius), Tegexidegeqi (rhizomata of Inula helenium, ripe fruits of Gardenia jasminoides, rhizomata of Platycodon grandiflorum, rhizomata of Coptis chinensis, heartwood of Caesalpinia sappan), Ligan Shiliu Bawei San (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piper longum, flowers of Carthamus tinctorius, ripe fruits of Amomum tsao-ko, rhizomata of Zingiber officinale), etc. Principles of Mongolian medicine in treating diseases: by balancing “three essences or roots” and “seven elements”, strengthening liver and kidney function, transporting nutrients to enhance physical strength and disease resistance, and combined with drugs for comprehensive conditioning treatment. However, their molecular mechanisms remain unclear. In this review, we prospect that Mongolian medicines might be a promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-κB inflammatory pathway via lipid-sensitive nuclear receptors (i.e., FXR and LXR).