Decade long upsurge in mutations associated with pyrethroid resistance in bed bug populations in the USA
Decade long upsurge in mutations associated with pyrethroid resistance in bed bug populations in the USA
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DOI：
10.1007/s10340-022-01505-4
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发表时间：
2022-04-20
影响因子：
4.8
通讯作者：
Booth，Warren
中科院分区：
文献类型：
--
作者：
Lewis，Cari D.;Levine，Brenna A.;Booth，Warren
在过去的三十年里，臭虫在全球范围内重新成为一种重要的室内害虫。在广泛使用二氯二苯三氯乙烷（DDT）的几年内，首次报道了一种涉及电压门控钠通道的低敲相关杀虫剂抗性（kdr），该抗性涉及有机氯和拟除虫菊酯杀虫剂，并被认为是导致该物种最近复苏的重要因素。从那时起，对拟除虫菊酯类杀虫剂的选择已经加强，但对其对kdr相关突变频率的短期影响知之甚少。在这里，我们报告了在美国从两个时间段收集的三种相关突变的频率的时间变化，采样间隔大约十年。结果显示，在此期间，kdr相关突变的频率显著增加，并且在最近收集的标本中没有杀虫剂敏感基因型。此外，还观察到具有多重dr相关突变的侵染的显著转变。这些发现表明，在过去十年中持续使用拟除虫菊酯类杀虫剂继续对c施加强大的选择压力。驱动kdr相关突变的增殖。他们证明，如果不减弱，强烈的人为选择可以推动适应性特征的快速进化。
Over the past three decades, the bed bugCimex lectulariushas resurged as a prominent indoor pest on a global scale. Knockdown-associated insecticide resistance (kdr) involving the voltage-gated sodium channel, targeted by organochlorine and pyrethroid insecticides, was first reported inC. lectulariuswithin a few years of the widespread use of dichlorodiphenyltrichloroethane (DDT) and has been implicated as a significant factor contributing to the species’ recent resurgence. Since then, selection with pyrethroid insecticides has intensified, yet little is known regarding its short-term impacts on the frequency ofkdr-associated mutations. Here, we report temporal changes in the frequencies of threekdr-associated mutations inC. lectulariuspopulations collected across the USA from two time periods, sampled approximately a decade apart. The results reveal a significant increase in the frequencies ofkdr-associated mutations over this period and the absence of the insecticide-susceptible genotype in recent collections. Furthermore, a significant transition was observed toward infestations possessing multiplekdr-associated mutations. These findings suggest that the persistent use of pyrethroid insecticides over the past decade continues to impose strong selection pressure onC. lectulariuspopulations, driving the proliferation ofkdr-associated mutations. They demonstrate that, if unabated, strong anthropogenic selection can drive the rapid evolution of adaptive traits.