SYNERGY OF FOSMIDOMYCIN (FR-31564) AND OTHER ANTIMICROBIAL AGENTS
SYNERGY OF FOSMIDOMYCIN (FR-31564) AND OTHER ANTIMICROBIAL AGENTS
复制标题
DOI：
10.1128/aac.22.4.560
复制
发表时间：
1982-01-01
影响因子：
4.9
通讯作者：
KAMIMURA, T
中科院分区：
文献类型：
--
作者：
NEU, HC;KAMIMURA, T
磷米霉素 (FR-31564) 是一种膦酸衍生物，与头孢唑啉、头孢氨苄、氨苄青霉素、羧苄青霉素、替卡西林、庆大霉素和甲氧苄啶联合使用。发现磷米霉素与青霉素或头孢菌素之间对 37-52% 的测试肠杆菌有协同作用。发现与甲氧苄啶对 55% 的分离细菌有协同作用，但只有 17% 的菌株表现出磷米霉素和庆大霉素之间的协同作用。磷米霉素和替卡西林之间对 35% 的假单胞菌分离株显示出协同作用。不同物种的头孢唑林、氨苄青霉素和庆大霉素耐药分离株均被福米霉素协同抑制，替卡西林和庆大霉素耐药分离株也受到协同抑制。没有遇到对抗。这项研究说明了攻击细菌细胞不同机制的化合物具有协同活性的另一个例子。
Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37-52% of the Enterobacteriaceae tested. Synergy with trimethoprim was found againt 55% of bacteria isolated, but only 17% of the strains showed synergy between fosmidomycin and gentamicin. Synergy between fosmidomycin and ticarcillin was shown for 35% of the Pseudomonas isolates. Cefazolin-, ampicillin- and gentamicin-resistant isolates of various species were synergistically inhibited by fosmidomycin, as were ticarcillin- and gentamicin-resistant isolates. Antagonism was not encountered. This study illustrates another example of synergistic activity of compounds which attack different mechanisms in bacterial cells.